In this issue: Tec Kinases in the Crosshairs

Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorder...

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Bibliographic Details
Published inInternational Reviews of Immunology Vol. 32; no. 2; pp. 85 - 86
Main Authors Faris, Mary, Bot, Adrian
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.04.2012
Taylor & Francis
Subjects
Humans
Inflammation - metabolism
Lymphocytes - immunology
Lymphocytes - metabolism
Neoplasms - metabolism
Protein-Tyrosine Kinases - metabolism
Signal Transduction - immunology
Translational Medical Research
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Summary:Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the discovery and development of molecular targeted therapies against Tec kinases, most notably to date Btk, already showing promising clinical activity in B cell lymphoma and autoimmunity. As Btk does not carry oncogenic modifications, this also establishes a novel therapeutic paradigm, based on targeting ancillary pathways recruited by the pathogenic process to become pivotal to cancer cell's biology. This issue focuses on biology and translation of Tec kinases, at the cross-roads between immunology and cancer.
Bibliography:SourceType-Other Sources-1
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ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0883-0185
1937-4364
1563-5244
DOI:10.3109/08830185.2012.671692