Elucidating the inhibitory mechanism of yeast α-glucosidase by phytocompounds from Scoparia dulcis through in vitro and in silico approach

• Published in: Journal of biomolecular structure & dynamics Vol. 41; no. 6; pp. 2574 - 2586
• Main Authors: Murugan, Gopinath, Rajkumar, Divya Sangeetha, Kaliyaperumal, Malarvizhi, Ramdoss, Ramya, Natarajan, Sasirekha, Padmanaban, Rajashree
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 13.04.2023
• Subjects: alpha-Glucosidases - chemistry; betulunic acid; enzyme kinetics; Hypoglycemic Agents - pharmacology; molecular docking; Molecular Docking Simulation; Saccharomyces cerevisiae; scopadulcic acid B; Scoparia - metabolism; Scoparia dulcis; α-glucosidase; α-glucosidase; molecular docking; scopadulcic acid B; betulunic acid; enzyme kinetics; Scoparia dulcis

Antidiabetic activity of herb Scoparia dulcis Linn (SD) used in traditional medicine is well established, yet, the molecular mechanism is not understood. In this study, in vitro α-glucosidase inhibitory effects of SD aqueous extract and its kinetics were investigated and in silico analysis was carri...