CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers

• Published in: Science (American Association for the Advancement of Science) Vol. 381; no. 6657; pp. 515 - 524
• Main Authors: Bill, Ruben, Wirapati, Pratyaksha, Messemaker, Marius, Roh, Whijae, Zitti, Beatrice, Duval, Florent, Kiss, Máté, Park, Jong Chul, Saal, Talia M., Hoelzl, Jan, Tarussio, David, Benedetti, Fabrizio, Tissot, Stéphanie, Kandalaft, Lana, Varrone, Marco, Ciriello, Giovanni, McKee, Thomas A., Monnier, Yan, Mermod, Maxime, Blaum, Emily M., Gushterova, Irena, Gonye, Anna L. K., Hacohen, Nir, Getz, Gad, Mempel, Thorsten R., Klein, Allon M., Weissleder, Ralph, Faquin, William C., Sadow, Peter M., Lin, Derrick, Pai, Sara I., Sade-Feldman, Moshe, Pittet, Mikael J.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 04.08.2023
• Subjects: Cancer; Cell Polarity - immunology; Cellular communication; Chemokine CXCL9 - analysis; Chemokine CXCL9 - metabolism; Communication networks; Gene expression; Head & neck cancer; Head and neck carcinoma; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - pathology; Humans; Immune system; Immunotherapy; Macrophages; Macrophages - immunology; Microenvironments; Osteopontin - analysis; Osteopontin - metabolism; Patients; Polarity; Prognosis; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - immunology; Squamous Cell Carcinoma of Head and Neck - pathology; Tumor Microenvironment; Tumors; Variation

Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused on tumor-to-tumor variation to examine 52 head and nec...