MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1

• Published in: Biochemical and biophysical research communications Vol. 632; pp. 92 - 99
• Main Authors: Zhou, Hai, Zhou, Jing, Teng, Hongwei, Yang, Hua, Qiu, Jinsong, Li, Xiangdong
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2022
• Subjects: animal models; apoptosis; bone marrow; brain; brain damage; BV2 cells; cell communication; cell cycle checkpoints; Exosomes; infarction; ischemia; Ischemic stroke; Mesenchymal stem cells; microRNA; neuroglia; oxidative stress; phenotype; stroke; BV2 cells; microRNA; Ischemic stroke; Exosomes; Mesenchymal stem cells

Mesenchymal stem cells-derived exosomes (MSCs-Exo) were able to exert neuroprotective effects in brain injury after ischemic stroke (IS). In addition, exosomes containing microRNAs (miRNAs) can be transported to recipient cells to mediate intercellular communication. It has been shown that the level...