Inhibition of Atherosclerotic Plaque Development by Oral Administration of α-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice

• Published in: Journal of the American College of Nutrition Vol. 38; no. 1; p. 15
• Main Authors: Sugasawa, Noriko, Katagi, Ayako, Kurobe, Hirotsugu, Nakayama, Taisuke, Nishio, Chika, Takumi, Hiroko, Higashiguchi, Fumiharu, Aihara, Ken-Ichi, Shimabukuro, Michio, Sata, Masataka, Kitagawa, Tetsuya
• Format: Journal Article
• Language: English
• Published: United States 02.01.2019
• Subjects: Administration, Oral; Animals; Antioxidants - administration & dosage; Apolipoproteins E - genetics; Cholesterol - blood; Diet, High-Fat; Glucosides - administration & dosage; Hesperidin - administration & dosage; Hesperidin - analogs & derivatives; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic - genetics; Plaque, Atherosclerotic - pathology; Plaque, Atherosclerotic - prevention & control; Apo-E KO mouse; hesperetin; supplements and functional foods; Atherosclerosis; hesperidin

Hesperidin, an abundant flavonoid in citrus fruit, and its aglycone, hesperetin, have been reported to possess various physiological activities, including antioxidant, anti-inflammatory, hypolipidemic, and antihypertensive activities. In this study, we investigated whether α-glucosyl hesperidin and...