Fabrication of liver-derived extracellular matrix nanofibers and functional evaluation in in vitro culture using primary hepatocytes

• Published in: Materialia Vol. 4; pp. 518 - 528
• Main Authors: Bual, Ronald, Kimura, Haruna, Ikegami, Yasuhiro, Shirakigawa, Nana, Ijima, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2018
• Subjects: Electrospun nanofibers; Gelatin; Liver-derived extracellular matrix; Polycaprolactone; Primary hepatocytes; Electrospun nanofibers; Liver-derived extracellular matrix; Gelatin; Polycaprolactone; Primary hepatocytes

Fabrication of functional scaffolds is one of the main goals of tissue engineering, particularly scaffolds mimicking the native extracellular matrix (ECM) and stimulating a microenvironment that supports cell growth and function. In this study, a scaffold was developed using liver-derived ECM (L-ECM...