Tropism and innate host responses of influenza A/H5N6 virus: an analysis of ex vivo and in vitro cultures of the human respiratory tract

• Published in: The European respiratory journal Vol. 49; no. 3; p. 1601710
• Main Authors: Hui, Kenrie P. Y., Chan, Louisa L. Y., Kuok, Denise I. T., Mok, Chris K. P., Yang, Zi-feng, Li, Run-feng, Luk, Geraldine S. M., Lee, Elaine F., Lai, Jimmy C. C., Yen, Hui-ling, Zhu, Huachen, Guan, Yi, Nicholls, John M., Peiris, J. S. Malik, Chan, Michael C. W.
• Format: Journal Article
• Language: English
• Published: England European Respiratory Society Journals Ltd 01.03.2017
• Subjects: Affinity; Alveolar Epithelial Cells - virology; Alveoli; Animals; Avian flu; Birds; Bronchus; Cells, Cultured; Chemokines; Chemokines - immunology; Cytokines; Cytokines - immunology; Epithelial cells; Humans; Immunity, Innate; Inflammation; Influenza A; Influenza A virus - pathogenicity; Influenza A virus - physiology; Influenza in Birds - immunology; Influenza, Human - immunology; Lungs; Male; Middle Aged; Nasopharynx; Public health; Replication; Respiratory System - pathology; Respiratory System - virology; Respiratory tract; Tissue Culture Techniques; Tropism; Viral Tropism; Virus Replication; Viruses

Since their first isolation in 2013, influenza A/H5N6 viruses have spread amongst poultry across multiple provinces in China and to Laos, Vietnam and Myanmar. So far, there have been 14 human H5N6 infections with 10 fatalities. We investigated the tropism, replication competence and cytokine inducti...