Inhibition of phagocytic activity of ARPE-19 cells by free radical mediated oxidative stress

• Published in: Free radical research Vol. 50; no. 8; pp. 887 - 897
• Main Authors: Olchawa, Magdalena M., Pilat, Anna K., Szewczyk, Grzegorz M., Sarna, Tadeusz Jan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.08.2016
• Subjects: Animals; Cattle; Cholesterol hydroperoxides; flow cytometry; Free Radicals - pharmacology; hydrogen peroxide; Hydrogen Peroxide - pharmacology; Oxidative Stress - drug effects; Phagocytes; photoreceptor outer segments; Retinal Pigment Epithelium - drug effects; rose Bengal; flow cytometry; photoreceptor outer segments; Cholesterol hydroperoxides; rose Bengal; hydrogen peroxide

Oxidative stress is a main factor responsible for key changes leading to the onset of age-related macular degeneration (ARMD) that occur in the retinal pigment epithelium (RPE), which is involved in phagocytosis of photoreceptor outer segments (POS). In this study, hydrogen peroxide (H 2 O 2 ), H 2...