Acute pulmonary and splenic response in an in vivo model of whole-body low-dose X-radiation exposure

• Published in: International journal of radiation biology Vol. 95; no. 8; pp. 1072 - 1084
• Main Authors: Puukila, Stephanie, Muise, Stacy, McEvoy, James, Bouchier, Tara, Hooker, Antony M., Boreham, Douglas R., Khaper, Neelam, Dixon, Dani-Louise
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.08.2019
• Subjects: Animals; Apoptosis - radiation effects; Cell Proliferation - radiation effects; Dose-Response Relationship, Radiation; Low dose; Lung - pathology; Lung - radiation effects; Male; Oxidative Stress - radiation effects; Radiation Dosage; Rats; respiratory mechanics; Respiratory Mechanics - radiation effects; Space life sciences; spleen; Spleen - pathology; Spleen - radiation effects; Whole-Body Irradiation; X-radiation; spleen; Low dose; X-radiation; respiratory mechanics

Purpose: Diagnostic radiation is an important part of patient care in the Intensive Care Unit; however, there is little data on the acute effects of exposure to these doses. We investigated pulmonary and splenic response 30 minutes, 4 hours or 24 hours after exposure to 2 mGy, 20 mGy, 200 mGy or 4 G...