Vasopressor responses and hypoxemia with acutely increased intracranial pressure

We studied anesthetized dogs subjected to graded increases in intracranial pressure (ICP) to assess the role of the systemic vasopressor (Cushing) response in the arterial hypoxemia associated with increased ICP. The arterial PO2 decrement was significantly greater with rapidly increased ICP compare...

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Bibliographic Details
Published inLife sciences (1973) Vol. 38; no. 19; p. 1767
Main Authors Millis, R M, Wood, D H, Trouth, C O
Format Journal Article
LanguageEnglish
Published Netherlands 12.05.1986
Subjects
Animals
Carbon Dioxide - blood
Cats
Dogs
Electric Stimulation
Hypertension - blood
Intracranial Pressure
Medulla Oblongata - physiology
Oxygen - blood
Time Factors
Vasomotor System - physiology
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Summary:We studied anesthetized dogs subjected to graded increases in intracranial pressure (ICP) to assess the role of the systemic vasopressor (Cushing) response in the arterial hypoxemia associated with increased ICP. The arterial PO2 decrement was significantly greater with rapidly increased ICP compared to slowly increased ICP (P less than 0.01). Systemic vasopressor responses generated in cats by direct electrical stimulation of the vasomotor center resulted in arterial hypoxemia during controlled ventilation. Therefore, arterial hypoxemia was coincident with increased systemic blood pressure produced by either elevation of ICP or electrical stimulation of the vasomotor center.
ISSN:0024-3205
DOI:10.1016/0024-3205(86)90127-X