Case Report: Anti-ADAM23 antibody: an overlooked autoantibody against VGKC-complex in autoimmune encephalitis

• Published in: Frontiers in immunology Vol. 16; p. 1589360
• Main Authors: Ni, Pinfei, Bai, Lin, Jiang, Nan, Fan, Siyuan, Yao, Ming, Ren, Haitao, Guan, Hongzhi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: ADAM Proteins - immunology; Aged; anti-ADAM23 antibody; Autoantibodies - blood; Autoantibodies - cerebrospinal fluid; Autoantibodies - immunology; autoimmune encephalitis; cell-based assay; Encephalitis - diagnosis; Encephalitis - drug therapy; Encephalitis - immunology; Female; Hashimoto Disease - diagnosis; Hashimoto Disease - drug therapy; Hashimoto Disease - immunology; Humans; Potassium Channels, Voltage-Gated - immunology; tissue-based assay; voltage-gated potassium channel complex; autoimmune encephalitis; voltage-gated potassium channel complex; cell-based assay; tissue-based assay; anti-ADAM23 antibody

Antibodies against voltage-gated potassium channel (VGKC) complexes include anti-LGI1 and anti-CASPR2. Anti-ADAM23 antibodies have not been previously reported in autoimmune encephalitis (AE). We report a 71-year-old female patient who presented with rapidly progressive short-term memory loss, psych...