The application of CD73 in minimal residual disease monitoring using flow cytometry in B-cell acute lymphoblastic leukemia
The expression of CD73 by flow cytometry (FC) in bone marrow (BM) specimens of B-cell acute lymphoblastic leukemia (B-ALL) with or without minimal residual disease (MRD) was studied, and its advantages were evaluated using the MRD assay. This study also detected the expression profile of CD73 in hem...
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Published in | Leukemia & lymphoma Vol. 57; no. 5; pp. 1174 - 1181 |
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Main Authors | , , , , , , , , , |
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Taylor & Francis
03.05.2016
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Abstract | The expression of CD73 by flow cytometry (FC) in bone marrow (BM) specimens of B-cell acute lymphoblastic leukemia (B-ALL) with or without minimal residual disease (MRD) was studied, and its advantages were evaluated using the MRD assay. This study also detected the expression profile of CD73 in hematogones and mature B cells in BM specimens of 18 healthy donors. Results showed that the mean value of CD73 expression in MRD-positive B cells was 6-fold greater than that in the MRD negative ones. Also, 41.82% MRD-positive B-ALL cases expressed high CD73 and the sensitivity of CD73-based MRD detection reached 10
−4
. Since the expression of CD73 increases with the maturation of normal B cells, it is better to mix it with CD34, CD10 and CD20 in one tube to prevent the disturbance of mature B cells. CD73 is recommended as an optional MRD marker for B-ALL patients by using FC. |
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AbstractList | The expression of CD73 by flow cytometry (FC) in bone marrow (BM) specimens of B-cell acute lymphoblastic leukemia (B-ALL) with or without minimal residual disease (MRD) was studied, and its advantages were evaluated using the MRD assay. This study also detected the expression profile of CD73 in hematogones and mature B cells in BM specimens of 18 healthy donors. Results showed that the mean value of CD73 expression in MRD-positive B cells was 6-fold greater than that in the MRD negative ones. Also, 41.82% MRD-positive B-ALL cases expressed high CD73 and the sensitivity of CD73-based MRD detection reached 10(-4). Since the expression of CD73 increases with the maturation of normal B cells, it is better to mix it with CD34, CD10 and CD20 in one tube to prevent the disturbance of mature B cells. CD73 is recommended as an optional MRD marker for B-ALL patients by using FC. The expression of CD73 by flow cytometry (FC) in bone marrow (BM) specimens of B-cell acute lymphoblastic leukemia (B-ALL) with or without minimal residual disease (MRD) was studied, and its advantages were evaluated using the MRD assay. This study also detected the expression profile of CD73 in hematogones and mature B cells in BM specimens of 18 healthy donors. Results showed that the mean value of CD73 expression in MRD-positive B cells was 6-fold greater than that in the MRD negative ones. Also, 41.82% MRD-positive B-ALL cases expressed high CD73 and the sensitivity of CD73-based MRD detection reached 10 −4 . Since the expression of CD73 increases with the maturation of normal B cells, it is better to mix it with CD34, CD10 and CD20 in one tube to prevent the disturbance of mature B cells. CD73 is recommended as an optional MRD marker for B-ALL patients by using FC. |
Author | Gong, Ming Wang, Wei Chen, Yan-Rong Ma, Yi-Gai Gao, Li Li, Yan Huang, Fan-Zhou Gao, Ya-Yue Li, Zhen-Ling Zhang, Chun-Xia |
Author_xml | – sequence: 1 givenname: Wei surname: Wang fullname: Wang, Wei organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 2 givenname: Li surname: Gao fullname: Gao, Li organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 3 givenname: Yan surname: Li fullname: Li, Yan organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 4 givenname: Zhen-Ling surname: Li fullname: Li, Zhen-Ling organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 5 givenname: Ming surname: Gong fullname: Gong, Ming organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 6 givenname: Fan-Zhou surname: Huang fullname: Huang, Fan-Zhou organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 7 givenname: Yan-Rong surname: Chen fullname: Chen, Yan-Rong organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 8 givenname: Chun-Xia surname: Zhang fullname: Zhang, Chun-Xia organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 9 givenname: Ya-Yue surname: Gao fullname: Gao, Ya-Yue organization: Department of Hematology, China-Japan Friendship Hospital – sequence: 10 givenname: Yi-Gai surname: Ma fullname: Ma, Yi-Gai email: dr_myg@163.com organization: Department of Hematology, China-Japan Friendship Hospital |
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SubjectTerms | 5'-Nucleotidase - genetics 5'-Nucleotidase - metabolism Adult Aged Antigens, CD - genetics Antigens, CD - metabolism B-cell acute lymphoblastic leukemia Biomarkers, Tumor Female Flow Cytometry Gene Expression Humans Immunophenotyping Male Middle Aged minimal residual disease Neoplasm, Residual - diagnosis Neoplasm, Residual - metabolism Polymerase Chain Reaction Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Sensitivity and Specificity |
Title | The application of CD73 in minimal residual disease monitoring using flow cytometry in B-cell acute lymphoblastic leukemia |
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