Mesencephalic astrocyte-derived neurotrophic factor restores blood-brain barrier integrity of aged mice after ischaemic stroke/reperfusion through anti-inflammation via TLR4/MyD88/NF-κB pathway

• Published in: Journal of drug targeting Vol. 30; no. 4; pp. 430 - 441
• Main Authors: Han, Dan, Li, Fengyang, Zhang, Haixia, Ji, Cheng, Shu, Qing, Wang, Cheng, Ni, Huanyu, Zhu, Yun, Wang, Siliang
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 21.04.2022
• Subjects: Animals; anti-inflammation; Anti-Inflammatory Agents - therapeutic use; Astrocytes; blood-brain barrier; Blood-Brain Barrier - metabolism; Brain Ischemia - drug therapy; Endothelial Cells - metabolism; Humans; Hydrogen Peroxide - metabolism; Infarction, Middle Cerebral Artery - drug therapy; Inflammation - drug therapy; Inflammation - metabolism; ischaemic stroke/reperfusion; Ischemic Stroke - drug therapy; Mesencephalic astrocyte-derived neurotrophic factor; Mice; Myeloid Differentiation Factor 88 - metabolism; Myeloid Differentiation Factor 88 - therapeutic use; Nerve Growth Factors - metabolism; Nerve Growth Factors - therapeutic use; NF-kappa B - metabolism; Reperfusion; senescent condition; Stroke - drug therapy; TLR4/MyD88/NF-κB p65; Toll-Like Receptor 4 - metabolism; Toll-Like Receptor 4 - therapeutic use; Water - metabolism; TLR4/MyD88/NF-κB p65; anti-inflammation; blood–brain barrier; senescent condition; ischaemic stroke/reperfusion; Mesencephalic astrocyte-derived neurotrophic factor

Ischaemic stroke remains a leading cause of disability and mortality worldwide and ageing-associated inflammation for the aged patients specifically leads to worse post-stroke blood-brain barrier (BBB) disruption than young subjects. Accordingly, suppression of excessive inflammation can alleviate B...