Mesencephalic astrocyte-derived neurotrophic factor restores blood-brain barrier integrity of aged mice after ischaemic stroke/reperfusion through anti-inflammation via TLR4/MyD88/NF-κB pathway - Han, Dan; Li, Fengyang; Zhang, Haixia; Ji, Cheng; Shu, Qing; Wang, Cheng; Ni, Huanyu; Zhu, Yun; Wang, Siliang (Journal of drug targeting, 2022)
Keywords: Animals; anti-inflammation; Anti-Inflammatory Agents - therapeutic use; Astrocytes; blood-brain barrier; Blood-Brain Barrier - metabolism; Brain Ischemia - drug therapy; Endothelial Cells - metabolism; Humans; Hydrogen Peroxide - metabolism; Infarction, Middle Cerebral Artery - drug therapy; Inflammation - drug therapy; Inflammation - metabolism; ischaemic stroke/reperfusion; Ischemic Stroke - drug therapy; Mesencephalic astrocyte-derived neurotrophic factor; Mice; Myeloid Differentiation Factor 88 - metabolism; Myeloid Differentiation Factor 88 - therapeutic use; Nerve Growth Factors - metabolism; Nerve Growth Factors - therapeutic use; NF-kappa B - metabolism; Reperfusion; senescent condition; Stroke - drug therapy; TLR4/MyD88/NF-κB p65; Toll-Like Receptor 4 - metabolism; Toll-Like Receptor 4 - therapeutic use; Water - metabolism; TLR4/MyD88/NF-κB p65; anti-inflammation; blood–brain barrier; senescent condition; ischaemic stroke/reperfusion; Mesencephalic astrocyte-derived neurotrophic factor