Lack of dopaminergic modulation of cognitive flexibility

• Published in: Cognitive and behavioral neurology Vol. 20; no. 4; p. 225
• Main Authors: Smyth, Shawn F, Beversdorf, David Q
• Format: Journal Article
• Language: English
• Published: United States 01.12.2007
• Subjects: Adult; Association Learning - drug effects; Association Learning - physiology; Brain - drug effects; Brain - physiology; Bromocriptine - pharmacology; Cognition - drug effects; Cognition - physiology; Creativity; Dopamine - physiology; Dopamine Agonists - pharmacology; Double-Blind Method; Female; Humans; Male; Mental Recall - drug effects; Mental Recall - physiology; Problem Solving - drug effects; Problem Solving - physiology; Reaction Time - drug effects; Reaction Time - physiology; Semantics

To evaluate performance on a cognitive flexibility task after administration of a dopaminergic agonist. L-3,4-dihydroxyphenylalanine, which is converted into dopamine and norepinephrine, results in a restriction of the semantic network in priming experiments. Recent evidence suggests that flexibilit...