High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro - Chen, Dongdong; Su, Wen; Choy, Ka-Tim; Chu, Yan Sing; Lin, Chi Ho; Yen, Hui-Ling (Antiviral research, 2024)
Keywords: Amino Acid Substitution; Animals; Antiviral Agents - pharmacology; Baloxavir; Cap-dependent endonuclease inhibitor; Deep mutational scanning; Dibenzothiepins - pharmacology; Dogs; Drug Resistance, Viral - genetics; Fitness; High-Throughput Nucleotide Sequencing; Humans; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - genetics; Influenza virus; Influenza, Human - drug therapy; Influenza, Human - virology; Madin Darby Canine Kidney Cells; Morpholines - pharmacology; Oxazines - pharmacology; Pyridones - pharmacology; Reduced susceptibility; RNA-Dependent RNA Polymerase - genetics; Thiepins - pharmacology; Triazines - pharmacology; Viral Proteins - genetics; Virus Replication - drug effects; Reduced susceptibility; Cap-dependent endonuclease inhibitor; Deep mutational scanning; Influenza virus; Baloxavir; Fitness