Evaluation of flavonoids from banana pseudostem and flower (quercetin and catechin) as potent inhibitors of α-glucosidase: An in silico perspective

• Published in: Journal of biomolecular structure & dynamics Vol. 40; no. 23; pp. 12491 - 12505
• Main Authors: Patil, Shashank M., Martiz, Reshma Mary, Ramu, Ramith, Shirahatti, Prithvi S., Prakash, Ashwini, Kumar, B. R. Prashantha, Kumar, Naveen
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2022
• Subjects: Acarbose - pharmacology; alpha-Amylases; alpha-Glucosidases - chemistry; antidiabetic effects; banana pseudostem and flower; Catechin; Diabetes mellitus; Flavonoids - chemistry; Flavonoids - pharmacology; Flowers - chemistry; Flowers - metabolism; Glycoside Hydrolase Inhibitors - chemistry; Hypoglycemic Agents - chemistry; in silico approach; Molecular Docking Simulation; Musa - metabolism; Plant Extracts - chemistry; Quercetin - chemistry; Quercetin - pharmacology; α-glucosidase; in silico approach; α-glucosidase; banana pseudostem and flower; Diabetes mellitus; antidiabetic effects

The amelioration of postprandial hyperglycemia in diabetic conditions could be accomplished by the inhibition of α-glucosidases, a set of intestinal carbohydrate digestive enzymes responsible for starch hydrolysis and its absorption. The ethnopharmacological profile of banana depicts the usage of di...