Effect of gamma sterilization on the properties of microneedle array transdermal patch system

• Published in: Drug development and industrial pharmacy Vol. 46; no. 4; p. 606
• Main Authors: Swathi, Honnavar Parthasarathy, Anusha Matadh, Vishwanath, Paul Guin, Jhimli, Narasimha Murthy, Sathyanarayana, Kanni, Paranjothy, Varshney, Lalit, Suresh, Sarasija, Shivakumar, Hagalavadi Nanjappa
• Format: Journal Article
• Language: English
• Published: England 02.04.2020
• Subjects: Calorimetry, Differential Scanning; Carboxymethylcellulose Sodium - chemistry; Carboxymethylcellulose Sodium - pharmacokinetics; Carboxymethylcellulose Sodium - radiation effects; Drug Delivery Systems - methods; Drug Liberation - radiation effects; Gamma Rays - adverse effects; Hyaluronic Acid - chemistry; Hyaluronic Acid - pharmacokinetics; Hyaluronic Acid - radiation effects; Hydrophobic and Hydrophilic Interactions - radiation effects; Polymers - chemistry; Polymers - pharmacokinetics; Polymers - radiation effects; Povidone - analogs & derivatives; Povidone - chemistry; Povidone - pharmacokinetics; Povidone - radiation effects; Solubility; Sterilization - methods; Transdermal Patch; X-Ray Diffraction; Soluble microneedles; sodium hyaluronate; transdermal; gamma sterilization; polyvinylpyrrolidone

Soluble microneedles (MNs) of four different hydrophilic polymers namely sodium carboxymethyl cellulose CMC), polyvinylpyrrolidone (PVP) K30, PVP K90 and sodium hyaluronate (HU) were fabricated by mold casting technique. When exposed to gamma radiation, a dose of 25 kilogray (kGy) was found to rende...