MicroRNA 26a targets Ezh2 to regulate apoptosis in mouse ovarian granulosa cells

• Published in: Systems biology in reproductive medicine Vol. 67; no. 3; pp. 221 - 229
• Main Authors: Huo, Shiwei, Qi, Hongrong, Si, Yuexiu, Li, Changzhou, Du, Wenyan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.05.2021
• Subjects: Animals; Apoptosis; Enhancer of Zeste Homolog 2 Protein; ezh2; Female; Follicular Atresia; granulosa cell; Granulosa Cells; Mice; MicroRNAs - genetics; Mir-26a; Ovary; rna interference; ezh2; apoptosis; granulosa cell; rna interference; Mir-26a

In the mammalian ovary, <1% of the follicles ovulate, with most undergoing degenerative atresia during ovarian follicular development. Follicular atresia is caused by the apoptosis of granulosa cells (GCs), although the precise underpinning mechanism remains unidentified. MiR-26a regulates variou...