The tricarboxylic acid (TCA) cycle: a malleable metabolic network to counter cellular stress
The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis via oxidative phosphorylation, mounting evidence reveals that this metabolic hub orchest...
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| Published in | Critical reviews in biochemistry and molecular biology Vol. 58; no. 1; pp. 81 - 97 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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England
Taylor & Francis
02.01.2023
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| Abstract | The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis via oxidative phosphorylation, mounting evidence reveals that this metabolic hub orchestrates a wide variety of pivotal biological processes. It plays an important part in combatting cellular stress by modulating NADH/NADPH homeostasis, scavenging ROS (reactive oxygen species), producing ATP by substrate-level phosphorylation, signaling and supplying metabolites to quell a range of cellular disruptions. This review elaborates on how the reprogramming of this network prompted by such abiotic stress as metal toxicity, oxidative tension, nutrient challenge and antibiotic insult is critical for countering these conditions in mostly microbial systems. The cross-talk between the stressors and the participants of TCA cycle that results in changes in metabolite and nucleotide concentrations aimed at combatting the abiotic challenge is presented. The fine-tuning of metabolites mediated by disparate enzymes associated with this metabolic hub is discussed. The modulation of enzymatic activities aimed at generating metabolic moieties dedicated to respond to the cellular perturbation is explained. This ancient metabolic network has to be recognized for its ability to execute a plethora of physiological functions beyond its well-established traditional roles. |
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| AbstractList | The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis via oxidative phosphorylation, mounting evidence reveals that this metabolic hub orchestrates a wide variety of pivotal biological processes. It plays an important part in combatting cellular stress by modulating NADH/NADPH homeostasis, scavenging ROS (reactive oxygen species), producing ATP by substrate-level phosphorylation, signaling and supplying metabolites to quell a range of cellular disruptions. This review elaborates on how the reprogramming of this network prompted by such abiotic stress as metal toxicity, oxidative tension, nutrient challenge and antibiotic insult is critical for countering these conditions in mostly microbial systems. The cross-talk between the stressors and the participants of TCA cycle that results in changes in metabolite and nucleotide concentrations aimed at combatting the abiotic challenge is presented. The fine-tuning of metabolites mediated by disparate enzymes associated with this metabolic hub is discussed. The modulation of enzymatic activities aimed at generating metabolic moieties dedicated to respond to the cellular perturbation is explained. This ancient metabolic network has to be recognized for its ability to execute a plethora of physiological functions beyond its well-established traditional roles.The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis via oxidative phosphorylation, mounting evidence reveals that this metabolic hub orchestrates a wide variety of pivotal biological processes. It plays an important part in combatting cellular stress by modulating NADH/NADPH homeostasis, scavenging ROS (reactive oxygen species), producing ATP by substrate-level phosphorylation, signaling and supplying metabolites to quell a range of cellular disruptions. This review elaborates on how the reprogramming of this network prompted by such abiotic stress as metal toxicity, oxidative tension, nutrient challenge and antibiotic insult is critical for countering these conditions in mostly microbial systems. The cross-talk between the stressors and the participants of TCA cycle that results in changes in metabolite and nucleotide concentrations aimed at combatting the abiotic challenge is presented. The fine-tuning of metabolites mediated by disparate enzymes associated with this metabolic hub is discussed. The modulation of enzymatic activities aimed at generating metabolic moieties dedicated to respond to the cellular perturbation is explained. This ancient metabolic network has to be recognized for its ability to execute a plethora of physiological functions beyond its well-established traditional roles. The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis via oxidative phosphorylation, mounting evidence reveals that this metabolic hub orchestrates a wide variety of pivotal biological processes. It plays an important part in combatting cellular stress by modulating NADH/NADPH homeostasis, scavenging ROS (reactive oxygen species), producing ATP by substrate-level phosphorylation, signaling and supplying metabolites to quell a range of cellular disruptions. This review elaborates on how the reprogramming of this network prompted by such abiotic stress as metal toxicity, oxidative tension, nutrient challenge and antibiotic insult is critical for countering these conditions in mostly microbial systems. The cross-talk between the stressors and the participants of TCA cycle that results in changes in metabolite and nucleotide concentrations aimed at combatting the abiotic challenge is presented. The fine-tuning of metabolites mediated by disparate enzymes associated with this metabolic hub is discussed. The modulation of enzymatic activities aimed at generating metabolic moieties dedicated to respond to the cellular perturbation is explained. This ancient metabolic network has to be recognized for its ability to execute a plethora of physiological functions beyond its well-established traditional roles. The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis oxidative phosphorylation, mounting evidence reveals that this metabolic hub orchestrates a wide variety of pivotal biological processes. It plays an important part in combatting cellular stress by modulating NADH/NADPH homeostasis, scavenging ROS (reactive oxygen species), producing ATP by substrate-level phosphorylation, signaling and supplying metabolites to quell a range of cellular disruptions. This review elaborates on how the reprogramming of this network prompted by such abiotic stress as metal toxicity, oxidative tension, nutrient challenge and antibiotic insult is critical for countering these conditions in mostly microbial systems. The cross-talk between the stressors and the participants of TCA cycle that results in changes in metabolite and nucleotide concentrations aimed at combatting the abiotic challenge is presented. The fine-tuning of metabolites mediated by disparate enzymes associated with this metabolic hub is discussed. The modulation of enzymatic activities aimed at generating metabolic moieties dedicated to respond to the cellular perturbation is explained. This ancient metabolic network has to be recognized for its ability to execute a plethora of physiological functions beyond its well-established traditional roles. |
| Author | Appanna, Vasu D. Legendre, Felix MacLean, Alex |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37125817$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nrmicro3032 10.1177/2042018820938240 10.1089/cell.2013.0049 10.3389/fmicb.2017.01424 10.1111/plb.12542 10.1016/j.biochi.2008.10.014 10.1016/S0162-0134(01)00307-5 10.1016/j.cmet.2015.01.008 10.1016/S0304-4165(02)00444-0 10.1007/s10482-010-9538-x 10.1371/journal.pgen.1002013 10.1155/2018/2568038 10.3389/fpls.2017.00172 10.1111/j.1462-2920.2010.02200.x 10.1128/AEM.02702-07 10.1016/S0162-0134(99)00120-8 10.1016/j.cell.2007.06.049 10.1038/s41579-021-00583-y 10.1099/jmm.0.001139 10.1016/j.jbiotec.2013.07.002 10.1002/jobm.200800007 10.1128/JB.00555-07 10.1128/JB.00046-09 10.1186/s12934-019-1230-x 10.1089/ars.2017.7216 10.1111/j.1574-6968.1995.tb07753.x 10.1016/j.bbagen.2014.09.028 10.1016/0304-4165(84)90150-8 10.3390/ijerph14121504 10.1007/BF01106775 10.1007/s00284-014-0751-0 10.3389/fpls.2017.01377 10.1371/journal.pone.0000690 10.1038/s41467-019-13668-3 10.1016/j.micres.2014.12.001 10.1016/j.jbbm.2005.07.005 10.3389/fmicb.2019.01929 10.3389/fpls.2020.552969 10.3389/fcell.2015.00040 10.1016/j.jbc.2022.102838 10.1186/s12870-020-02788-4 10.1038/s12276-020-00504-8 10.1111/pce.12682 10.1007/s00792-008-0150-1 10.1111/jipb.12690 10.1089/ars.2007.1672 10.1016/S0065-2911(08)60165-4 10.1128/JB.00099-08 10.1007/s10482-019-01372-7 10.1146/annurev-nutr-080508-141119 10.1021/ic0512072 10.1016/j.redox.2020.101674 10.1016/j.abb.2016.07.011 10.3389/fpls.2017.01767 10.3390/cells8050384 10.3390/antiox11030560 10.1007/s40502-020-00553-1 10.1016/j.addr.2009.03.012 10.1093/oxfordjournals.pcp.a029266 10.1016/j.micres.2021.126865 10.1007/s00284-003-4100-y 10.1104/pp.108.127472 10.1046/j.1365-3040.2002.00754.x 10.1002/etc.5620120707 10.1155/2013/219840 10.1104/pp.96.3.737 10.1080/10715762.2018.1457217 10.1007/s12011-017-1119-7 10.1007/978-1-4614-1533-6_144 10.1016/j.enzmictec.2016.01.007 10.1016/S0176-1617(11)80672-3 10.1371/journal.ppat.1003893 10.1007/s10482-015-0629-6 10.1104/pp.103.3.685 10.1371/journal.pone.0002682 10.1007/s11274-020-02900-8 10.1007/s10534-006-9024-0 10.1016/j.bbrc.2004.03.157 10.1111/j.1574-6968.1992.tb05272.x 10.21638/spbu03.2018.103 10.1007/978-94-017-1435-8_10 10.1016/j.biotechadv.2012.11.008 10.1016/j.toxlet.2011.03.019 10.1186/s12934-015-0238-0 10.1371/journal.pone.0007344 10.1016/j.redox.2015.11.010 10.1016/j.bbabio.2016.03.012 10.1007/s10482-017-0829-3 10.1111/jam.12497 10.4161/psb.21949 10.1016/S0944-5013(97)80029-8 10.1111/jam.13509 10.1111/j.1365-3040.2005.01476.x 10.1016/j.metabol.2021.154733 10.1016/j.chembiol.2016.12.015 10.1074/jbc.M411979200 10.1016/j.jbiotec.2015.01.029 10.1016/S0899-9007(02)00825-0 |
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| Keywords | NADPH NADH keto-acids TCA cycle metabolic reprogramming cellular stress |
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| References | CIT0072 CIT0074 CIT0073 CIT0076 CIT0075 CIT0078 CIT0111 CIT0077 CIT0070 Lemire J (CIT0054) 2010 CIT0113 CIT0079 CIT0112 CIT0115 CIT0117 CIT0116 CIT0118 CIT0083 CIT0082 CIT0085 CIT0084 CIT0086 CIT0088 CIT0081 CIT0080 CIT0003 CIT0002 Duruibe JO (CIT0033) 2007; 2 CIT0005 CIT0004 CIT0007 CIT0006 CIT0009 CIT0008 CIT0094 CIT0093 CIT0096 CIT0095 CIT0010 CIT0098 CIT0097 CIT0012 CIT0011 CIT0099 CIT0090 CIT0092 Appanna VD (CIT0013) 1998; 93 CIT0091 CIT0014 CIT0016 CIT0015 CIT0018 CIT0017 CIT0019 CIT0021 CIT0020 CIT0023 Lemire J (CIT0056) 2010; 309 CIT0022 Zhao RZ (CIT0114) 2019; 44 CIT0025 CIT0024 CIT0027 CIT0028 CIT0030 Masindi V (CIT0071) 2018; 6 CIT0031 CIT0034 CIT0036 CIT0035 CIT0038 CIT0037 CIT0039 CIT0041 CIT0040 CIT0042 CIT0045 CIT0044 CIT0046 CIT0049 CIT0048 CIT0050 CIT0052 CIT0051 CIT0053 CIT0058 CIT0057 Lemire J (CIT0055) 2010; 6 CIT0059 CIT0060 CIT0063 CIT0062 CIT0065 CIT0064 CIT0067 CIT0100 CIT0066 CIT0109 CIT0069 CIT0068 CIT0104 CIT0103 CIT0106 CIT0108 |
| References_xml | – ident: CIT0046 doi: 10.1038/nrmicro3032 – ident: CIT0060 doi: 10.1177/2042018820938240 – ident: CIT0118 doi: 10.1089/cell.2013.0049 – volume: 2 start-page: 112 issue: 5 year: 2007 ident: CIT0033 publication-title: Inter J Phys Sci – ident: CIT0080 doi: 10.3389/fmicb.2017.01424 – ident: CIT0085 doi: 10.1111/plb.12542 – ident: CIT0069 doi: 10.1016/j.biochi.2008.10.014 – ident: CIT0038 doi: 10.1016/S0162-0134(01)00307-5 – ident: CIT0084 doi: 10.1016/j.cmet.2015.01.008 – ident: CIT0039 doi: 10.1016/S0304-4165(02)00444-0 – ident: CIT0068 doi: 10.1007/s10482-010-9538-x – ident: CIT0077 doi: 10.1371/journal.pgen.1002013 – ident: CIT0045 doi: 10.1155/2018/2568038 – ident: CIT0072 doi: 10.3389/fpls.2017.00172 – volume: 44 start-page: 3 issue: 1 year: 2019 ident: CIT0114 publication-title: Int J Mol Med – volume: 6 start-page: 1384 year: 2010 ident: CIT0055 publication-title: Environ Microbiol doi: 10.1111/j.1462-2920.2010.02200.x – ident: CIT0027 doi: 10.1128/AEM.02702-07 – ident: CIT0037 doi: 10.1016/S0162-0134(99)00120-8 – ident: CIT0048 doi: 10.1016/j.cell.2007.06.049 – ident: CIT0062 doi: 10.1038/s41579-021-00583-y – ident: CIT0064 doi: 10.1099/jmm.0.001139 – ident: CIT0024 doi: 10.1016/j.jbiotec.2013.07.002 – ident: CIT0053 doi: 10.1002/jobm.200800007 – ident: CIT0099 doi: 10.1128/JB.00555-07 – ident: CIT0097 doi: 10.1128/JB.00046-09 – ident: CIT0115 doi: 10.1186/s12934-019-1230-x – ident: CIT0109 doi: 10.1089/ars.2017.7216 – volume: 6 start-page: e04691 year: 2018 ident: CIT0071 publication-title: Heavy Metals – ident: CIT0011 doi: 10.1111/j.1574-6968.1995.tb07753.x – ident: CIT0117 doi: 10.1016/j.bbagen.2014.09.028 – ident: CIT0116 doi: 10.1016/0304-4165(84)90150-8 – ident: CIT0081 doi: 10.3390/ijerph14121504 – ident: CIT0083 doi: 10.1007/BF01106775 – ident: CIT0091 doi: 10.1007/s00284-014-0751-0 – ident: CIT0049 doi: 10.3389/fpls.2017.01377 – ident: CIT0066 doi: 10.1371/journal.pone.0000690 – ident: CIT0070 doi: 10.1038/s41467-019-13668-3 – ident: CIT0005 doi: 10.1016/j.micres.2014.12.001 – volume: 93 start-page: 147 issue: 376 year: 1998 ident: CIT0013 publication-title: Microbios – ident: CIT0096 doi: 10.1016/j.jbbm.2005.07.005 – ident: CIT0008 doi: 10.3389/fmicb.2019.01929 – ident: CIT0031 doi: 10.3389/fpls.2020.552969 – ident: CIT0016 doi: 10.3389/fcell.2015.00040 – volume: 309 start-page: 170 issue: 2 year: 2010 ident: CIT0056 publication-title: FEMS Microbiol Lett – ident: CIT0015 doi: 10.1016/j.jbc.2022.102838 – ident: CIT0059 doi: 10.1186/s12870-020-02788-4 – ident: CIT0111 doi: 10.1038/s12276-020-00504-8 – ident: CIT0086 doi: 10.1111/pce.12682 – ident: CIT0067 doi: 10.1007/s00792-008-0150-1 – ident: CIT0113 doi: 10.1111/jipb.12690 – ident: CIT0112 doi: 10.1089/ars.2007.1672 – ident: CIT0035 doi: 10.1016/S0065-2911(08)60165-4 – ident: CIT0028 doi: 10.1128/JB.00099-08 – ident: CIT0050 doi: 10.1007/s10482-019-01372-7 – ident: CIT0036 doi: 10.1146/annurev-nutr-080508-141119 – ident: CIT0044 doi: 10.1021/ic0512072 – ident: CIT0079 doi: 10.1016/j.redox.2020.101674 – ident: CIT0009 doi: 10.1016/j.abb.2016.07.011 – ident: CIT0025 doi: 10.3389/fpls.2017.01767 – ident: CIT0100 doi: 10.3390/cells8050384 – ident: CIT0052 doi: 10.3390/antiox11030560 – ident: CIT0022 doi: 10.1007/s40502-020-00553-1 – ident: CIT0093 doi: 10.1016/j.addr.2009.03.012 – ident: CIT0063 doi: 10.1093/oxfordjournals.pcp.a029266 – ident: CIT0065 doi: 10.1016/j.micres.2021.126865 – ident: CIT0014 doi: 10.1007/s00284-003-4100-y – ident: CIT0103 doi: 10.1104/pp.108.127472 – ident: CIT0094 doi: 10.1046/j.1365-3040.2002.00754.x – ident: CIT0034 doi: 10.1002/etc.5620120707 – ident: CIT0092 doi: 10.1155/2013/219840 – ident: CIT0075 doi: 10.1104/pp.96.3.737 – ident: CIT0076 doi: 10.1080/10715762.2018.1457217 – ident: CIT0020 doi: 10.1007/s12011-017-1119-7 – ident: CIT0018 doi: 10.1007/978-1-4614-1533-6_144 – ident: CIT0007 doi: 10.1016/j.enzmictec.2016.01.007 – ident: CIT0021 doi: 10.1016/S0176-1617(11)80672-3 – ident: CIT0090 doi: 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| Snippet | The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily... |
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| SubjectTerms | Adenosine Triphosphate - metabolism cellular stress Citric Acid Cycle Humans keto-acids Metabolic Networks and Pathways metabolic reprogramming NADH NADPH Reactive Oxygen Species - metabolism TCA cycle Tricarboxylic Acids |
| Title | The tricarboxylic acid (TCA) cycle: a malleable metabolic network to counter cellular stress |
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