Quantitative proteomic analysis of down syndrome biomarkers in maternal serum using isobaric tags for relative and absolute quantification (iTRAQ)

• Published in: Gynecological endocrinology Vol. 36; no. 6; pp. 489 - 495
• Main Authors: Zhao, Sheng-Long, Liu, Xiao-Wei, Wu, Shao-Wen, Zheng, Yuan-Yuan, Zhang, Wei-Yuan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.06.2020
• Subjects: Adult; aneuploidy; Biomarkers - analysis; Biomarkers - blood; Case-Control Studies; Down Syndrome - blood; Down Syndrome - diagnosis; Female; Humans; Maternal Age; Maternal Serum Screening Tests - methods; Predictive Value of Tests; Pregnancy; Prenatal diagnosis; Prenatal Diagnosis - methods; proteomics; Proteomics - methods; trisomy 21; aneuploidy; Prenatal diagnosis; proteomics; trisomy 21

Prenatal diagnosis of Down syndrome (DS) is based on calculated risk involving maternal age, biochemical and ultrasonographic markers, and, more recently, cell-free DNA (cfDNA). The present study was designed to identify Down Syndrome biomarkers in maternal serum. We quantified the changes in matern...