Risk alleles for multiple sclerosis in multiplex families

• Published in: Neurology Vol. 72; no. 23; p. 1984
• Main Authors: D'Netto, M J, Ward, H, Morrison, K M, Ramagopalan, S V, Dyment, D A, DeLuca, G C, Handunnetthi, L, Sadovnick, A D, Ebers, G C
• Format: Journal Article
• Language: English
• Published: United States 09.06.2009
• Subjects: Alleles; Case-Control Studies; CD58 Antigens - genetics; Chromosome Mapping; DNA Mutational Analysis; Family; Female; Gene Frequency - genetics; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; Genetic Testing; Genetic Variation - genetics; Genome-Wide Association Study; Genotype; Histocompatibility Antigens - genetics; Humans; Interleukin-2 Receptor alpha Subunit - genetics; Lectins, C-Type - genetics; Linkage Disequilibrium - genetics; Male; Molecular Epidemiology - methods; Monosaccharide Transport Proteins - genetics; Multiple Sclerosis - epidemiology; Multiple Sclerosis - genetics; Multiple Sclerosis - immunology; Nuclear Proteins - genetics; Pedigree; Polymorphism, Single Nucleotide - genetics; Prevalence; Receptors, Interleukin-7 - genetics; Risk Factors

We assessed the hypotheses that non-major histocompatibility complex multiple sclerosis (MS) susceptibility loci would be common to sporadic cases and multiplex families, that they would have larger effects in multiplex families, and that the aggregation of susceptibility loci contributes to the inc...