Effect of Curcuma kwangsiensis polysaccharides on blood lipid profiles and oxidative stress in high-fat rats

We have investigated the protective effect of polysaccharides from Curcuma kwangsiensis (CKP) against oxidative injury in rats fed high-fat diet. The protective effect of CKP was compared with Lovastatin, a well-known antioxidant. Sixty SD rats were used for the experimental study. Oxidative injury...

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Published inInternational journal of biological macromolecules Vol. 44; no. 2; pp. 138 - 142
Main Authors Xu, Chen, Haiyan, Zhong, Hua, Zhu, Jianhong, Zeng, Pin, Dai
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2009
Subjects
Animals
Antioxidant
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Chromatography, High Pressure Liquid
CKP
Curcuma - chemistry
Dietary Fats - administration & dosage
Dietary Fats - pharmacology
Glutathione Peroxidase - blood
GSH-Px
HDL-c
Lipids - blood
Liver - drug effects
Liver - metabolism
Malondialdehyde - blood
Oxidative Stress - drug effects
Polysaccharides - analysis
Polysaccharides - pharmacology
Rat
Rats
SOD
Superoxide Dismutase - blood
Triglycerides - blood
HDL-c
CKP
SOD
GSH-Px
Rat
Antioxidant
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Abstract We have investigated the protective effect of polysaccharides from Curcuma kwangsiensis (CKP) against oxidative injury in rats fed high-fat diet. The protective effect of CKP was compared with Lovastatin, a well-known antioxidant. Sixty SD rats were used for the experimental study. Oxidative injury was induced by feeding high-fat diet for 3 weeks. The blood profiles, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-c) levels during experimental period were significantly increased in untreated model control group, whereas high-density lipoprotein cholesterol (HDL-c) levels and antioxidant enzymes activities significantly decreased in untreated model control group. The levels of TC, TG, LDL-c levels in CKP-treated rats were decreased significantly when compared to the untreated model control group, which were brought down to near normal in CKP-treated group. HDL-c level and antioxidant enzymes activities were found to be significantly increased in serum of CKP-treated group compared to the untreated model control group. The protective effect of CKP against oxidative injury was comparable to that of Lovastatin. Our data suggest that CKP exerts its protective effect by modulating the extent of lipid peroxidation and augmenting antioxidant defense system and thus protects the experimental animals against oxidative injury induced by high-fat diet treatment.
AbstractList We have investigated the protective effect of polysaccharides from Curcuma kwangsiensis (CKP) against oxidative injury in rats fed high-fat diet. The protective effect of CKP was compared with Lovastatin, a well-known antioxidant. Sixty SD rats were used for the experimental study. Oxidative injury was induced by feeding high-fat diet for 3 weeks. The blood profiles, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-c) levels during experimental period were significantly increased in untreated model control group, whereas high-density lipoprotein cholesterol (HDL-c) levels and antioxidant enzymes activities significantly decreased in untreated model control group. The levels of TC, TG, LDL-c levels in CKP-treated rats were decreased significantly when compared to the untreated model control group, which were brought down to near normal in CKP-treated group. HDL-c level and antioxidant enzymes activities were found to be significantly increased in serum of CKP-treated group compared to the untreated model control group. The protective effect of CKP against oxidative injury was comparable to that of Lovastatin. Our data suggest that CKP exerts its protective effect by modulating the extent of lipid peroxidation and augmenting antioxidant defense system and thus protects the experimental animals against oxidative injury induced by high-fat diet treatment.
We have investigated the protective effect of polysaccharides from Curcuma kwangsiensis (CKP) against oxidative injury in rats fed high-fat diet. The protective effect of CKP was compared with Lovastatin, a well-known antioxidant. Sixty SD rats were used for the experimental study. Oxidative injury was induced by feeding high-fat diet for 3 weeks. The blood profiles, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-c) levels during experimental period were significantly increased in untreated model control group, whereas high-density lipoprotein cholesterol (HDL-c) levels and antioxidant enzymes activities significantly decreased in untreated model control group. The levels of TC, TG, LDL-c levels in CKP-treated rats were decreased significantly when compared to the untreated model control group, which were brought down to near normal in CKP-treated group. HDL-c level and antioxidant enzymes activities were found to be significantly increased in serum of CKP-treated group compared to the untreated model control group. The protective effect of CKP against oxidative injury was comparable to that of Lovastatin. Our data suggest that CKP exerts its protective effect by modulating the extent of lipid peroxidation and augmenting antioxidant defense system and thus protects the experimental animals against oxidative injury induced by high-fat diet treatment.
Author Hua, Zhu
Jianhong, Zeng
Pin, Dai
Xu, Chen
Haiyan, Zhong
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SOD
GSH-Px
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Snippet We have investigated the protective effect of polysaccharides from Curcuma kwangsiensis (CKP) against oxidative injury in rats fed high-fat diet. The...
We have investigated the protective effect of polysaccharides from Curcuma kwangsiensis (CKP) against oxidative injury in rats fed high-fat diet. The...
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SubjectTerms Animals
Antioxidant
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Chromatography, High Pressure Liquid
CKP
Curcuma - chemistry
Dietary Fats - administration & dosage
Dietary Fats - pharmacology
Glutathione Peroxidase - blood
GSH-Px
HDL-c
Lipids - blood
Liver - drug effects
Liver - metabolism
Malondialdehyde - blood
Oxidative Stress - drug effects
Polysaccharides - analysis
Polysaccharides - pharmacology
Rat
Rats
SOD
Superoxide Dismutase - blood
Triglycerides - blood
Title Effect of Curcuma kwangsiensis polysaccharides on blood lipid profiles and oxidative stress in high-fat rats
URI https://dx.doi.org/10.1016/j.ijbiomac.2008.11.005
https://www.ncbi.nlm.nih.gov/pubmed/19059430
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