Possible role of WNT10B in increased proliferation and tubule formation of human umbilical vein endothelial cell cultures treated with hypoxic conditioned medium from human adipocytes

• Published in: Biotechnic & histochemistry Vol. 97; no. 3; pp. 168 - 179
• Main Authors: Pourdashti, Sara, Faridi, Nassim, Yaghooti, Hamid, Jalali, Mohammad-Taha, Soroush, Ahmadreza, Bathaie, S. Zahra
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2022
• Subjects: Adipocytes; Adipose tissue; angiogenesis; Cell Proliferation; conditioned medium; Culture Media, Conditioned - metabolism; Culture Media, Conditioned - pharmacology; human; Human Umbilical Vein Endothelial Cells - metabolism; Humans; hypoxia; Hypoxia - metabolism; Neovascularization, Physiologic; normoxia; Proto-Oncogene Proteins - metabolism; umbilical vein; VEGFA; Wnt Proteins - metabolism; WNT10B; β-catenin; conditioned medium; WNT10B; hypoxia; β-catenin; Adipose tissue; angiogenesis; umbilical vein; normoxia; human; VEGFA

Regulation of angiogenesis plays an important role in adipose tissue expansion and function. The Wnt pathway and WNT10B, the main member of Wnt family, participate in angiogenesis in cancer tumors, but there is limited evidence to support the regulatory role of WNT10B in human adipose tissue angioge...