Synergistic mechanotherapy and sonopermeation guided by mathematical modeling for solid tumor treatment

• Published in: Frontiers in Drug Delivery Vol. 5
• Main Authors: Koutsi, Marina, Stylianopoulos, Triantafyllos, Mpekris, Fotios
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 24.06.2025
• Subjects: breast cancer; computational modeling; Drug Delivery; nano-immunotherapy; tumor microenvironment

The progression of tumors and their response to treatment are significantly influenced by the presence of elevated mechanical solid stress. This solid stress compresses intratumoral blood vessels, leading to reduced blood flow (hypoperfusion) and insufficient oxygen levels (hypoxia), both of which h...