Screening of mitochondrial tRNA mutations in 300 infants with hearing loss

• Published in: Mitochondrial DNA. Part A. DNA mapping, sequencing, and analysis Vol. 30; no. 2; pp. 345 - 350
• Main Authors: Tang, Kai, Gao, Ziying, Han, Chunling, Zhao, Suolin, Du, Xiaoyun, Wang, Wenjuan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.02.2019
• Subjects: Adult; Conserved Sequence; DNA, Mitochondrial - genetics; Female; Hearing loss; Hearing Loss - blood; Hearing Loss - genetics; Humans; Infant; Male; mitochondrial mutations; Mutation; pathogenic; Reactive Oxygen Species - blood; RNA, Transfer - genetics; tRNA; pathogenic; tRNA; mitochondrial mutations; Hearing loss

Mitochondrial DNA (MtDNA) mutations are the important causes for hearing loss. To see the contribution of mtDNA to deafness, we screened for mutations in mt-tRNA genes from 300 deaf infants and 200 healthy subjects. Moreover, we analyzed the mtDNA copy number and ROS levels in patients carrying the...