On the possible role of reactive oxygen species in angiogenesis

• Published in: Advances in experimental medicine and biology Vol. 454; p. 295
• Main Authors: Lelkes, P I, Hahn, K L, Sukovich, D A, Karmiol, S, Schmidt, D H
• Format: Journal Article
• Language: English
• Published: United States 1998
• Subjects: Cell Hypoxia - physiology; Cell Respiration; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular - cytology; Endothelium, Vascular - physiology; Humans; Kinetics; Laminin; Microcirculation - physiology; Neovascularization, Physiologic - physiology; NF-kappa B - metabolism; Oxygen Consumption; Protein Kinase C - metabolism; Proteoglycans; Reactive Oxygen Species - physiology; Skin - blood supply

Human microvascular endothelial cells grown on a 3-D reconstituted extracellular matrix (Matrigel) spontaneously and rapidly form a capillary network of tubular structures, thus modeling part of the angiogenic cascade. Exposure of the cells at the time of plating onto Matrigel to a brief episode of...