Interaction of circulating TGFβ regulatory miRNAs in different severity of diabetic kidney disease

• Published in: Archives of physiology and biochemistry Vol. ahead-of-print; no. ahead-of-print; pp. 1 - 15
• Main Authors: Ren, Huiwen, Shao, Ying, Ma, Xiaoyu, An, Li, Liu, Yu, Wang, Qiuyue
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.06.2024
• Subjects: bioinformatics; Circulating MicroRNA - blood; Circulating MicroRNA - genetics; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetic kidney disease; Diabetic Nephropathies - blood; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Female; Gene Expression Regulation; Glycated Hemoglobin - metabolism; Humans; Male; Mesangial Cells - metabolism; microRNA; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Severity of Illness Index; Transforming Growth Factor beta - metabolism; Transforming Growth Factor beta1 - blood; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; transforming growth factor β; urinary albumin excretion rate; microRNA; urinary albumin excretion rate; transforming growth factor β; bioinformatics; Diabetic kidney disease
• ISSN: 1381-3455; 1744-4160; 1744-4160
• DOI: 10.1080/13813455.2022.2034884

To explore the interaction of TGFβ regulatory microRNAs (miRNAs) with different severities of diabetic kidney disease (DKD). According to different UACR (30 and 300 mg/g), 436 subjects were included, and high glucose induced RMCs were cultured. Real-time PCR, ELISA, and automatic biochemical analysi...