Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial

• Published in: Thorax Vol. 64; no. 7; pp. 581 - 586
• Main Authors: Alonso-Fernandez, A, Garcia-Rio, F, Arias, M A, Hernanz, A, de la Pena, M, Pierola, J, Barcelo, A, Lopez-Collazo, E, Agusti, A
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group 01.07.2009
• Subjects: Adult; Aged; Biological and medical sciences; Blood Pressure - physiology; Cardiology. Vascular system; Continuous Positive Airway Pressure; Dinoprost - analogs & derivatives; Dinoprost - blood; Double-Blind Method; Humans; Male; Medical sciences; Middle Aged; Nitrates - blood; Nitrites - blood; Oxidative Stress; Pneumology; Prospective Studies; Respiratory system : syndromes and miscellaneous diseases; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - physiopathology; Sleep Apnea, Obstructive - therapy; Oxidative stress; Nervous system diseases; Sleep apnea syndrome; Respiratory disease; Efficiency; Anesthesia; Nitrates; Circulatory system; Cardiology

Previous studies have presented contradictory data concerning obstructive sleep apnoea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability. This study was undertaken to (1) compare the concentration of 8-isoprostane and total nitrate and nitrite (NOx) in plasma of middle-aged men...