Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder

There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no...

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Published inInternational journal of neuroscience Vol. 132; no. 8; pp. 826 - 834
Main Authors Bilgiç, Ayhan, Abuşoğlu, Sedat, Sadıç Çelikkol, Çağla, Oflaz, Mehmet Burhan, Akça, Ömer Faruk, Sivrikaya, Abdullah, Baysal, Tamer, Ünlü, Ali
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.08.2022
Subjects
Autism spectrum disorder
kynurenine
preschool children
toddlers
tryptophan
preschool children
toddlers
kynurenine
Autism spectrum disorder
tryptophan
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Abstract There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.
AbstractList AIMThere are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. MATERIALS AND METHODSA total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. RESULTSSerum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. CONCLUSIONSThese findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.
There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.
Author Baysal, Tamer
Akça, Ömer Faruk
Sadıç Çelikkol, Çağla
Oflaz, Mehmet Burhan
Ünlü, Ali
Abuşoğlu, Sedat
Sivrikaya, Abdullah
Bilgiç, Ayhan
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tryptophan
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Snippet There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial...
AIMThere are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial...
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SubjectTerms Autism spectrum disorder
kynurenine
preschool children
toddlers
tryptophan
Title Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
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