Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder
There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no...
Saved in:
Published in | International journal of neuroscience Vol. 132; no. 8; pp. 826 - 834 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis
03.08.2022
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD.
A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system.
Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower.
These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood. |
---|---|
AbstractList | AIMThere are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. MATERIALS AND METHODSA total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. RESULTSSerum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. CONCLUSIONSThese findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood. There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood. |
Author | Baysal, Tamer Akça, Ömer Faruk Sadıç Çelikkol, Çağla Oflaz, Mehmet Burhan Ünlü, Ali Abuşoğlu, Sedat Sivrikaya, Abdullah Bilgiç, Ayhan |
Author_xml | – sequence: 1 givenname: Ayhan orcidid: 0000-0003-0703-2630 surname: Bilgiç fullname: Bilgiç, Ayhan organization: Department of Child and Adolescent Psychiatry, Meram School of Medicine, Necmettin Erbakan University – sequence: 2 givenname: Sedat surname: Abuşoğlu fullname: Abuşoğlu, Sedat organization: Department of Biochemistry, School of Medicine, Selcuk University – sequence: 3 givenname: Çağla surname: Sadıç Çelikkol fullname: Sadıç Çelikkol, Çağla organization: Department of Child and Adolescent Psychiatry, Meram School of Medicine, Necmettin Erbakan University – sequence: 4 givenname: Mehmet Burhan surname: Oflaz fullname: Oflaz, Mehmet Burhan organization: Department of Pediatric Cardiology, Meram School of Medicine, Necmettin Erbakan University – sequence: 5 givenname: Ömer Faruk surname: Akça fullname: Akça, Ömer Faruk organization: Department of Child and Adolescent Psychiatry, Meram School of Medicine, Necmettin Erbakan University – sequence: 6 givenname: Abdullah surname: Sivrikaya fullname: Sivrikaya, Abdullah organization: Department of Biochemistry, School of Medicine, Selcuk University – sequence: 7 givenname: Tamer surname: Baysal fullname: Baysal, Tamer organization: Department of Pediatric Cardiology, Meram School of Medicine, Necmettin Erbakan University – sequence: 8 givenname: Ali surname: Ünlü fullname: Ünlü, Ali organization: Department of Biochemistry, School of Medicine, Selcuk University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33086922$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1r3DAQhkVJaTZpfkKLjrl4qw_Lkm8NIWkKgVzas5ClMSsqS64kZ9l_Hy-76bGnmYHnnWGeK3QRUwSEvlCypUSRb4QwIlvRbtnabKlqKVXyA9pQ0fFGMNlfoM2RaY7QJbopxQ_rzPueKfUJXXJOVNcztkHTXaiQweE_h7hkiD4Cnk3d7c0BT1DNkIKvgAO8QijYR1yTcwFywSY6PGcodpdSwHbng1vzeO_rDpul-jLhMoOteZmw8yVlB_kz-jiaUODmXK_R78eHX_dPzfPLj5_3d8-N5V1XGwl0sKMTHQgHQpIWrJK9akcljBOcCWLNIHveiZ5J1pqBtuBoP3brj9TRgV-j29PeOae_C5SqJ18shGAipKVo1greKSWVXFFxQm1OpWQY9Zz9ZPJBU6KPsvW7bH2Urc-y19zX84llmMD9S72rXYHvJ8DHMeXJ7FMOTldzCCmP2UTri-b_v_EG2DiRxA |
CitedBy_id | crossref_primary_10_1002_aur_3044 crossref_primary_10_3390_cells12071087 crossref_primary_10_3389_fpsyt_2024_1333717 crossref_primary_10_1016_j_ynstr_2023_100543 crossref_primary_10_1177_13623613241246911 crossref_primary_10_1111_jpi_12715 crossref_primary_10_1038_s41398_023_02687_w crossref_primary_10_3390_medicina59111906 |
Cites_doi | 10.1111/jnc.14843 10.3945/ajcn.113.064998 10.1017/S1462399406000068 10.1016/j.pnpbp.2017.10.009 10.1016/j.psyneuen.2010.09.012 10.1159/000336646 10.1176/appi.books.9780890425596 10.1007/s40272-020-00408-0 10.15585/mmwr.ss6706a1 10.1046/j.1471-4159.1998.70010299.x 10.1016/j.neuropharm.2013.02.006 10.1016/j.neuropharm.2020.108174 10.1177/1099800417738363 10.1007/s00702-005-0432-z 10.1186/2040-2392-4-16 10.1038/sj.npp.1300188 10.1016/j.bcp.2012.07.030 10.1016/j.neuro.2015.08.003 10.1016/j.psychres.2011.09.029 10.1111/bdi.12814 10.1016/j.intimp.2013.08.018 10.1017/S1461145710001689 10.1002/bmc.4156 10.1186/s12993-015-0080-x 10.1007/BF00964611 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2 10.1523/JNEUROSCI.10-09-02965.1990 10.1080/13510002.2017.1343223 10.1111/j.1469-7610.1980.tb01797.x 10.4137/IJTR.S4282 10.1177/1178646917691938 10.1016/j.jad.2019.05.028 10.1523/JNEUROSCI.21-19-07463.2001 10.1007/BF02408436 10.1159/000086295 10.1016/j.ajpath.2011.05.048 10.1016/j.neuroscience.2012.12.052 10.1016/j.neuropharm.2016.03.024 10.1007/s10882-006-9026-4 10.1016/j.neuint.2008.01.013 10.1016/j.heliyon.2018.e00763 10.1016/j.brainresbull.2015.02.001 10.1159/000488157 10.1016/j.jpsychires.2015.05.007 10.1002/aur.1565 10.1016/j.jaac.2013.10.013 10.2174/1568026618666181115093136 10.2174/1871527317666180720163221 10.1017/S2045796018000483 |
ContentType | Journal Article |
Copyright | 2020 Informa UK Limited, trading as Taylor & Francis Group 2020 |
Copyright_xml | – notice: 2020 Informa UK Limited, trading as Taylor & Francis Group 2020 |
DBID | NPM AAYXX CITATION 7X8 |
DOI | 10.1080/00207454.2020.1841187 |
DatabaseName | PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Chemistry |
EISSN | 1563-5279 1543-5245 |
EndPage | 834 |
ExternalDocumentID | 10_1080_00207454_2020_1841187 33086922 1841187 |
Genre | Original Articles Journal Article |
GroupedDBID | --- 00X 03L 0BK 0R~ 29J 36B 4.4 5GY AAJNR AALUX AAMIU AAPUL AAPXX AAQRR ABBKH ABDBF ABEIZ ABIVO ABLKL ABPTK ABUPF ACENM ACFUF ACGEJ ACGFS ACLSK ADCVX ADFCX ADRBQ ADXPE AECIN AENEX AEOZL AEYQI AFKVX AFWLO AGDLA AGFJD AGRBW AGYJP AIJEM AIRBT AJWEG AKBVH ALIIL ALMA_UNASSIGNED_HOLDINGS ALQZU BABNJ BLEHA BOHLJ CCCUG CS3 CXMEQ DKSSO DU5 EAP EBS EPS ESX F5P FEDTE H13 HZ~ KRBQP KSSTO KWAYT KYCEM LJTGL M4Z O9- P2P RNANH RVRKI TFDNU TFL TFW TWFNG V1S ABLIJ ABXYU ACIEZ ALYBC EAS EBC EBD EBX EMB EMK EMOBN EPL HVGLF NPM SV3 TBQAZ TDBHL TERGH TUROJ TUS AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c366t-7e1bcfd56e5de5704ec87984f85ad53250cab7936592724ab14ed19f60021d1b3 |
ISSN | 0020-7454 |
IngestDate | Fri Oct 25 07:38:54 EDT 2024 Fri Aug 23 01:46:15 EDT 2024 Wed Oct 16 00:40:51 EDT 2024 Tue Jun 13 19:15:14 EDT 2023 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Keywords | preschool children toddlers kynurenine Autism spectrum disorder tryptophan |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c366t-7e1bcfd56e5de5704ec87984f85ad53250cab7936592724ab14ed19f60021d1b3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-0703-2630 |
PMID | 33086922 |
PQID | 2453688787 |
PQPubID | 23479 |
PageCount | 9 |
ParticipantIDs | informaworld_taylorfrancis_310_1080_00207454_2020_1841187 crossref_primary_10_1080_00207454_2020_1841187 pubmed_primary_33086922 proquest_miscellaneous_2453688787 |
PublicationCentury | 2000 |
PublicationDate | 2022-08-03 |
PublicationDateYYYYMMDD | 2022-08-03 |
PublicationDate_xml | – month: 08 year: 2022 text: 2022-08-03 day: 03 |
PublicationDecade | 2020 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | International journal of neuroscience |
PublicationTitleAlternate | Int J Neurosci |
PublicationYear | 2022 |
Publisher | Taylor & Francis |
Publisher_xml | – name: Taylor & Francis |
References | Yilmaz-Irmak T (CIT0031) 2007; 14 CIT0032 CIT0034 CIT0033 CIT0036 CIT0035 CIT0038 CIT0037 CIT0039 CIT0041 CIT0040 CIT0043 CIT0042 CIT0001 CIT0045 CIT0044 CIT0003 CIT0047 CIT0002 CIT0046 CIT0005 CIT0049 CIT0004 CIT0048 CIT0007 Sucuoglu B (CIT0030) 1996; 4 CIT0006 CIT0009 CIT0008 CIT0050 CIT0052 CIT0051 CIT0010 CIT0012 CIT0011 CIT0014 CIT0013 CIT0016 CIT0015 CIT0018 CIT0017 CIT0019 CIT0020 CIT0023 CIT0022 Curzon G. (CIT0021) 1979; 15 CIT0025 CIT0024 CIT0027 CIT0026 CIT0029 CIT0028 |
References_xml | – ident: CIT0023 doi: 10.1111/jnc.14843 – ident: CIT0025 doi: 10.3945/ajcn.113.064998 – ident: CIT0005 doi: 10.1017/S1462399406000068 – ident: CIT0052 doi: 10.1016/j.pnpbp.2017.10.009 – ident: CIT0006 doi: 10.1016/j.psyneuen.2010.09.012 – ident: CIT0036 doi: 10.1159/000336646 – ident: CIT0027 doi: 10.1176/appi.books.9780890425596 – ident: CIT0047 doi: 10.1007/s40272-020-00408-0 – ident: CIT0003 doi: 10.15585/mmwr.ss6706a1 – ident: CIT0011 doi: 10.1046/j.1471-4159.1998.70010299.x – ident: CIT0016 doi: 10.1016/j.neuropharm.2013.02.006 – ident: CIT0050 doi: 10.1016/j.neuropharm.2020.108174 – ident: CIT0032 doi: 10.1177/1099800417738363 – volume: 4 start-page: 116 year: 1996 ident: CIT0030 publication-title: Psychiatr Psychol Psychopharmacol (3P) J contributor: fullname: Sucuoglu B – ident: CIT0049 doi: 10.1007/s00702-005-0432-z – volume: 14 start-page: 13 year: 2007 ident: CIT0031 publication-title: Turk J Child Adolesc Mental Health contributor: fullname: Yilmaz-Irmak T – ident: CIT0017 doi: 10.1186/2040-2392-4-16 – ident: CIT0035 doi: 10.1038/sj.npp.1300188 – ident: CIT0034 doi: 10.1016/j.bcp.2012.07.030 – ident: CIT0040 doi: 10.1016/j.neuro.2015.08.003 – ident: CIT0007 doi: 10.1016/j.psychres.2011.09.029 – volume: 15 start-page: 81 year: 1979 ident: CIT0021 publication-title: J Neural Transm contributor: fullname: Curzon G. – ident: CIT0038 doi: 10.1111/bdi.12814 – ident: CIT0012 doi: 10.1016/j.intimp.2013.08.018 – ident: CIT0039 doi: 10.1017/S1461145710001689 – ident: CIT0033 doi: 10.1002/bmc.4156 – ident: CIT0043 doi: 10.1186/s12993-015-0080-x – ident: CIT0020 doi: 10.1007/BF00964611 – ident: CIT0037 doi: 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2 – ident: CIT0046 doi: 10.1523/JNEUROSCI.10-09-02965.1990 – ident: CIT0009 doi: 10.1080/13510002.2017.1343223 – ident: CIT0029 doi: 10.1111/j.1469-7610.1980.tb01797.x – ident: CIT0044 doi: 10.4137/IJTR.S4282 – ident: CIT0004 doi: 10.1177/1178646917691938 – ident: CIT0041 doi: 10.1016/j.jad.2019.05.028 – ident: CIT0015 doi: 10.1523/JNEUROSCI.21-19-07463.2001 – ident: CIT0028 doi: 10.1007/BF02408436 – ident: CIT0024 doi: 10.1159/000086295 – ident: CIT0013 doi: 10.1016/j.ajpath.2011.05.048 – ident: CIT0048 doi: 10.1016/j.neuroscience.2012.12.052 – ident: CIT0026 doi: 10.1016/j.neuropharm.2016.03.024 – ident: CIT0045 doi: 10.1007/s10882-006-9026-4 – ident: CIT0042 doi: 10.1016/j.neuint.2008.01.013 – ident: CIT0022 doi: 10.1016/j.heliyon.2018.e00763 – ident: CIT0014 doi: 10.1016/j.brainresbull.2015.02.001 – ident: CIT0010 doi: 10.1159/000488157 – ident: CIT0051 doi: 10.1016/j.jpsychires.2015.05.007 – ident: CIT0018 doi: 10.1002/aur.1565 – ident: CIT0001 doi: 10.1016/j.jaac.2013.10.013 – ident: CIT0008 doi: 10.2174/1568026618666181115093136 – ident: CIT0019 doi: 10.2174/1871527317666180720163221 – ident: CIT0002 doi: 10.1017/S2045796018000483 |
SSID | ssib002399288 ssj0002595 |
Score | 2.4128141 |
Snippet | There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial... AIMThere are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial... |
SourceID | proquest crossref pubmed informaworld |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 826 |
SubjectTerms | Autism spectrum disorder kynurenine preschool children toddlers tryptophan |
Title | Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder |
URI | https://www.tandfonline.com/doi/abs/10.1080/00207454.2020.1841187 https://www.ncbi.nlm.nih.gov/pubmed/33086922 https://search.proquest.com/docview/2453688787 |
Volume | 132 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELZK9wAXBLs8lpeMxHKpUjWx49jHtlCtkBYOdKW9RYnjsFXTFLWNUPmn_BvGdpyk2kW8LmnltLHr-Tqe9yD0hnEuRyrMPMml8miQ515KZOaxkMicijygptjzxUd2fkk_XIVXvd6PTtRStUuH8vuteSX_QlUYA7rqLNm_oGzzUBiA90BfuAKF4fpHNB5rVzdIjMu9TvcttcCoOwx_S_a6MzSQVycYDwodF2TCXndrbY3YbF11gK0twXmQ0D1IYMHb1cCkYG6qlXbhmPqcXTH20I7YqT7RKY_ZuusXxZeFcchHhhPtr1tEjtPqbBqeidlaS7ViVlTGHKuypAnH-QwghHsT3z5ioF94pIrFcmm7g9mBpH5Ac8x8yovEWMcv1DXsxmBSbdzEtZUDFGQdlUEaXM5vNBzpMnXQgCNqa1EPVc3HGQEd2_apaRh9a0mtXKSwZds8YF0JwJpXbxwuLhozGOnZhrBMGORUN2xvT9MmxrG-cwcdwTII76Oj8eTdZNaRlYQIeFvaHvRQ226j_jUu3UwXgr9tygNB6qDM7q-VJSM0zR-g-7W2g8cWug9RT5XH6GQMyFmv9vgtNvHHxrFzjO5OXe_BE7SqkY1bZOMa2bhFNrbIxosSO2RjQDZukI0dsrFGNrbIxg7Z2CH7EbqcvZ9Pz726MYgnCWM7L1J-KvMsZMBkVBiNqJI8EpzmPEyykIBUL5MUNl2HDEQBTVKfqswXufZB-5mfkseoX65L9RRhQdIkpSzlMgJdgjAuJAXuFSaCBooE4hQN3S7HX239l9hvyupassSaLHFNllMkurSIdwa5uQVtTH7z3deOcDFsuHbdJaVaV9s4MGvjkf7ME0vRZjmEjDgTQfDsP2Z-ju61_7oXqA9UUC9B2t6lr2rc_gQG4MyI |
link.rule.ids | 315,783,787,27938,27939 |
linkProvider | EBSCOhost |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Altered+kynurenine+pathway+metabolite+levels+in+toddlers+and+preschool+children+with+autism+spectrum+disorder&rft.jtitle=International+journal+of+neuroscience&rft.au=Bilgi%C3%A7%2C+Ayhan&rft.au=Abu%C5%9Fo%C4%9Flu%2C+Sedat&rft.au=Sad%C4%B1%C3%A7+%C3%87elikkol%2C+%C3%87a%C4%9Fla&rft.au=Oflaz%2C+Mehmet+Burhan&rft.date=2022-08-03&rft.pub=Taylor+%26+Francis&rft.issn=0020-7454&rft.eissn=1563-5279&rft.volume=132&rft.issue=8&rft.spage=826&rft.epage=834&rft_id=info:doi/10.1080%2F00207454.2020.1841187&rft.externalDocID=1841187 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0020-7454&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0020-7454&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0020-7454&client=summon |