Psoralen Isolated from the Roots of Dorstenia psilurus Welw. Modulate Th1/Th2 Cytokines and Inflammatory Enzymes in LPS-Stimulated RAW 264.7 Macrophages

• Published in: Mediators of inflammation Vol. 2024; no. 1; p. 8233689
• Main Authors: Isa, Adamu Imam, Fouotsa, Hugues, Mohammed, Osama A, Alghamdi, Mushabab, Adamu, Bappa, Alfaifi, Jaber, Jibo, Abubakar Mohammed, Alamri, Mohannad Mohammed Saleh, Khan, Sameer, Adam, Masoud Ishag Elkhalifa, Alqarni, Abdullah Ali, Mohamed, Mohamed O'haj, Ateba, Joël Eddy Terence, Dzoyem, Jean Paul
• Format: Journal Article
• Language: English
• Published: United States Hindawi Limited 2024; Wiley
• Subjects: Animals; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Cell proliferation; Chromatography; Cytokines; Cytokines - metabolism; Dorstenia; Enzymes; Ficusin - chemistry; Ficusin - pharmacology; Herbal medicine; Infections; Inflammation; Inflammatory diseases; Interleukins; Lipopolysaccharides - pharmacology; Lipoxygenase; Lymphocytes T; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Medical research; Medicinal plants; Mice; Natural products; Nitric oxide; Nitric Oxide - metabolism; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Roots - chemistry; Prostaglandin endoperoxide synthase; Psoralen; RAW 264.7 Cells; Th1 Cells - drug effects; Th1 Cells - metabolism; Th2 Cells - drug effects; Th2 Cells - metabolism; Tumor necrosis factor-α; Viral infections; γ-Interferon; Brazil; Mexico; Cameroon; Panama; Ethiopia; Germany

is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this activity and the main active ingredients of have not yet been fully characterized. This study aimed to isolate and identify the main active anti-in...