Psoralen Isolated from the Roots of Dorstenia psilurus Welw. Modulate Th1/Th2 Cytokines and Inflammatory Enzymes in LPS-Stimulated RAW 264.7 Macrophages
is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this activity and the main active ingredients of have not yet been fully characterized. This study aimed to isolate and identify the main active anti-in...
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| Published in | Mediators of inflammation Vol. 2024; no. 1; p. 8233689 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Hindawi Limited
2024
Wiley |
| Subjects | |
| Online Access | Get full text |
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| Abstract | is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this activity and the main active ingredients of
have not yet been fully characterized. This study aimed to isolate and identify the main active anti-inflammatory constituents of the
extract and to investigate the underlying anti-inflammatory mechanisms in murine macrophages. Chromatographic techniques and spectroscopic data were used for compound isolation and structure elucidation. The Griess reagent method and the ferrous oxidation-xylenol orange assay were used to evaluate the inhibition of NO production and 15-lipoxygenase activity, respectively. Cyclooxygenase activity was assessed using the fluorometric COX activity assay kit, and Th1/Th2 cytokine measurement was performed using a flow cytometer. The results indicated that the extract and fractions of
inhibit NO production and proliferation of RAW 264.7 macrophage cells. Bioguided fractionation led to the identification of psoralen, a furocoumarin, as the main bioactive anti-inflammatory compound. Psoralen inhibited NO production and 15-lipoxygenase activity and reduced pro-inflammatory Th1 cytokines (IFN-
, TNF-
, and IL-2) while increasing the secretion of anti-inflammatory cytokines (IL-4, IL-6, and IL-10) in activated RAW 264.7 macrophage cells. The encouraging results obtained in this study suggest that psoralen-based multiple modulation strategies could be a useful approach to address the treatment of inflammatory diseases. |
|---|---|
| AbstractList | Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this activity and the main active ingredients of D. psilurus have not yet been fully characterized. This study aimed to isolate and identify the main active anti-inflammatory constituents of the D. psilurus extract and to investigate the underlying anti-inflammatory mechanisms in murine macrophages. Chromatographic techniques and spectroscopic data were used for compound isolation and structure elucidation. The Griess reagent method and the ferrous oxidation-xylenol orange assay were used to evaluate the inhibition of NO production and 15-lipoxygenase activity, respectively. Cyclooxygenase activity was assessed using the fluorometric COX activity assay kit, and Th1/Th2 cytokine measurement was performed using a flow cytometer. The results indicated that the extract and fractions of D. psilurus inhibit NO production and proliferation of RAW 264.7 macrophage cells. Bioguided fractionation led to the identification of psoralen, a furocoumarin, as the main bioactive anti-inflammatory compound. Psoralen inhibited NO production and 15-lipoxygenase activity and reduced pro-inflammatory Th1 cytokines (IFN-γ, TNF-α, and IL-2) while increasing the secretion of anti-inflammatory cytokines (IL-4, IL-6, and IL-10) in activated RAW 264.7 macrophage cells. The encouraging results obtained in this study suggest that psoralen-based multiple modulation strategies could be a useful approach to address the treatment of inflammatory diseases.Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this activity and the main active ingredients of D. psilurus have not yet been fully characterized. This study aimed to isolate and identify the main active anti-inflammatory constituents of the D. psilurus extract and to investigate the underlying anti-inflammatory mechanisms in murine macrophages. Chromatographic techniques and spectroscopic data were used for compound isolation and structure elucidation. The Griess reagent method and the ferrous oxidation-xylenol orange assay were used to evaluate the inhibition of NO production and 15-lipoxygenase activity, respectively. Cyclooxygenase activity was assessed using the fluorometric COX activity assay kit, and Th1/Th2 cytokine measurement was performed using a flow cytometer. The results indicated that the extract and fractions of D. psilurus inhibit NO production and proliferation of RAW 264.7 macrophage cells. Bioguided fractionation led to the identification of psoralen, a furocoumarin, as the main bioactive anti-inflammatory compound. Psoralen inhibited NO production and 15-lipoxygenase activity and reduced pro-inflammatory Th1 cytokines (IFN-γ, TNF-α, and IL-2) while increasing the secretion of anti-inflammatory cytokines (IL-4, IL-6, and IL-10) in activated RAW 264.7 macrophage cells. The encouraging results obtained in this study suggest that psoralen-based multiple modulation strategies could be a useful approach to address the treatment of inflammatory diseases. Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this activity and the main active ingredients of D. psilurus have not yet been fully characterized. This study aimed to isolate and identify the main active anti-inflammatory constituents of the D. psilurus extract and to investigate the underlying anti-inflammatory mechanisms in murine macrophages. Chromatographic techniques and spectroscopic data were used for compound isolation and structure elucidation. The Griess reagent method and the ferrous oxidation-xylenol orange assay were used to evaluate the inhibition of NO production and 15-lipoxygenase activity, respectively. Cyclooxygenase activity was assessed using the fluorometric COX activity assay kit, and Th1/Th2 cytokine measurement was performed using a flow cytometer. The results indicated that the extract and fractions of D. psilurus inhibit NO production and proliferation of RAW 264.7 macrophage cells. Bioguided fractionation led to the identification of psoralen, a furocoumarin, as the main bioactive anti-inflammatory compound. Psoralen inhibited NO production and 15-lipoxygenase activity and reduced pro-inflammatory Th1 cytokines (IFN- γ , TNF- α , and IL-2) while increasing the secretion of anti-inflammatory cytokines (IL-4, IL-6, and IL-10) in activated RAW 264.7 macrophage cells. The encouraging results obtained in this study suggest that psoralen-based multiple modulation strategies could be a useful approach to address the treatment of inflammatory diseases. Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain‐related conditions. However, the anti‐inflammatory mechanisms underlying this activity and the main active ingredients of D. psilurus have not yet been fully characterized. This study aimed to isolate and identify the main active anti‐inflammatory constituents of the D. psilurus extract and to investigate the underlying anti‐inflammatory mechanisms in murine macrophages. Chromatographic techniques and spectroscopic data were used for compound isolation and structure elucidation. The Griess reagent method and the ferrous oxidation‐xylenol orange assay were used to evaluate the inhibition of NO production and 15‐lipoxygenase activity, respectively. Cyclooxygenase activity was assessed using the fluorometric COX activity assay kit, and Th1/Th2 cytokine measurement was performed using a flow cytometer. The results indicated that the extract and fractions of D. psilurus inhibit NO production and proliferation of RAW 264.7 macrophage cells. Bioguided fractionation led to the identification of psoralen, a furocoumarin, as the main bioactive anti‐inflammatory compound. Psoralen inhibited NO production and 15‐lipoxygenase activity and reduced pro‐inflammatory Th1 cytokines (IFN‐ γ , TNF‐ α , and IL‐2) while increasing the secretion of anti‐inflammatory cytokines (IL‐4, IL‐6, and IL‐10) in activated RAW 264.7 macrophage cells. The encouraging results obtained in this study suggest that psoralen‐based multiple modulation strategies could be a useful approach to address the treatment of inflammatory diseases. is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this activity and the main active ingredients of have not yet been fully characterized. This study aimed to isolate and identify the main active anti-inflammatory constituents of the extract and to investigate the underlying anti-inflammatory mechanisms in murine macrophages. Chromatographic techniques and spectroscopic data were used for compound isolation and structure elucidation. The Griess reagent method and the ferrous oxidation-xylenol orange assay were used to evaluate the inhibition of NO production and 15-lipoxygenase activity, respectively. Cyclooxygenase activity was assessed using the fluorometric COX activity assay kit, and Th1/Th2 cytokine measurement was performed using a flow cytometer. The results indicated that the extract and fractions of inhibit NO production and proliferation of RAW 264.7 macrophage cells. Bioguided fractionation led to the identification of psoralen, a furocoumarin, as the main bioactive anti-inflammatory compound. Psoralen inhibited NO production and 15-lipoxygenase activity and reduced pro-inflammatory Th1 cytokines (IFN- , TNF- , and IL-2) while increasing the secretion of anti-inflammatory cytokines (IL-4, IL-6, and IL-10) in activated RAW 264.7 macrophage cells. The encouraging results obtained in this study suggest that psoralen-based multiple modulation strategies could be a useful approach to address the treatment of inflammatory diseases. |
| Author | Alghamdi, Mushabab Dzoyem, Jean Paul Fouotsa, Hugues Jibo, Abubakar Mohammed Adam, Masoud Ishag Elkhalifa Adamu, Bappa Alamri, Mohannad Mohammed Saleh Khan, Sameer Mohamed, Mohamed O'haj Ateba, Joël Eddy Terence Isa, Adamu Imam Alqarni, Abdullah Ali Alfaifi, Jaber Mohammed, Osama A |
| AuthorAffiliation | 5 Department of Child Health College of Medicine University of Bisha , Bisha 61922, Saudi Arabia 9 Department of Biochemistry Faculty of Science University of Dschang , Dschang, Cameroon 8 Department of Clinical Biochemistry College of Medicine University of Bisha , Bisha 61922, Saudi Arabia 3 Department of Pharmacology College of Medicine University of Bisha , Bisha 61922, Saudi Arabia 1 Department of Physiology College of Medicine University of Bisha , Bisha 61922, Saudi Arabia 4 Department of Internal Medicine College of Medicine University of Bisha , P.O. Box 3752, Bisha, Asir 67713, Saudi Arabia 7 Department of Medical Education and Department of Medicine College of Medicine University of Bisha , Bisha, Saudi Arabia 6 Department of Family and Community Medicine College of Medicine University of Bisha , Bisha 61922, Saudi Arabia 2 Department of Process Engineering National Higher Polytechnic School of Douala University of Douala , Douala, Cameroon |
| AuthorAffiliation_xml | – name: 7 Department of Medical Education and Department of Medicine College of Medicine University of Bisha , Bisha, Saudi Arabia – name: 9 Department of Biochemistry Faculty of Science University of Dschang , Dschang, Cameroon – name: 2 Department of Process Engineering National Higher Polytechnic School of Douala University of Douala , Douala, Cameroon – name: 4 Department of Internal Medicine College of Medicine University of Bisha , P.O. Box 3752, Bisha, Asir 67713, Saudi Arabia – name: 1 Department of Physiology College of Medicine University of Bisha , Bisha 61922, Saudi Arabia – name: 6 Department of Family and Community Medicine College of Medicine University of Bisha , Bisha 61922, Saudi Arabia – name: 3 Department of Pharmacology College of Medicine University of Bisha , Bisha 61922, Saudi Arabia – name: 8 Department of Clinical Biochemistry College of Medicine University of Bisha , Bisha 61922, Saudi Arabia – name: 5 Department of Child Health College of Medicine University of Bisha , Bisha 61922, Saudi Arabia |
| Author_xml | – sequence: 1 givenname: Adamu Imam orcidid: 0000-0003-2470-0944 surname: Isa fullname: Isa, Adamu Imam organization: Department of Physiology College of Medicine University of Bisha, Bisha 61922, Saudi Arabia – sequence: 2 givenname: Hugues orcidid: 0000-0001-9524-9295 surname: Fouotsa fullname: Fouotsa, Hugues organization: Department of Process Engineering National Higher Polytechnic School of Douala University of Douala, Douala, Cameroon – sequence: 3 givenname: Osama A orcidid: 0000-0001-9712-9609 surname: Mohammed fullname: Mohammed, Osama A organization: Department of Pharmacology College of Medicine University of Bisha, Bisha 61922, Saudi Arabia – sequence: 4 givenname: Mushabab surname: Alghamdi fullname: Alghamdi, Mushabab organization: Department of Internal Medicine College of Medicine University of Bisha, P.O. Box 3752, Bisha, Asir 67713, Saudi Arabia – sequence: 5 givenname: Bappa surname: Adamu fullname: Adamu, Bappa organization: Department of Internal Medicine College of Medicine University of Bisha, P.O. Box 3752, Bisha, Asir 67713, Saudi Arabia – sequence: 6 givenname: Jaber orcidid: 0000-0002-4507-3970 surname: Alfaifi fullname: Alfaifi, Jaber organization: Department of Child Health College of Medicine University of Bisha, Bisha 61922, Saudi Arabia – sequence: 7 givenname: Abubakar Mohammed surname: Jibo fullname: Jibo, Abubakar Mohammed organization: Department of Family and Community Medicine College of Medicine University of Bisha, Bisha 61922, Saudi Arabia – sequence: 8 givenname: Mohannad Mohammed Saleh surname: Alamri fullname: Alamri, Mohannad Mohammed Saleh organization: Department of Family and Community Medicine College of Medicine University of Bisha, Bisha 61922, Saudi Arabia – sequence: 9 givenname: Sameer surname: Khan fullname: Khan, Sameer organization: Department of Physiology College of Medicine University of Bisha, Bisha 61922, Saudi Arabia – sequence: 10 givenname: Masoud Ishag Elkhalifa surname: Adam fullname: Adam, Masoud Ishag Elkhalifa organization: Department of Medical Education and Department of Medicine College of Medicine University of Bisha, Bisha, Saudi Arabia – sequence: 11 givenname: Abdullah Ali surname: Alqarni fullname: Alqarni, Abdullah Ali organization: Department of Internal Medicine College of Medicine University of Bisha, P.O. Box 3752, Bisha, Asir 67713, Saudi Arabia – sequence: 12 givenname: Mohamed O'haj surname: Mohamed fullname: Mohamed, Mohamed O'haj organization: Department of Clinical Biochemistry College of Medicine University of Bisha, Bisha 61922, Saudi Arabia – sequence: 13 givenname: Joël Eddy Terence orcidid: 0000-0002-1807-8346 surname: Ateba fullname: Ateba, Joël Eddy Terence organization: Department of Process Engineering National Higher Polytechnic School of Douala University of Douala, Douala, Cameroon – sequence: 14 givenname: Jean Paul orcidid: 0000-0003-3568-6711 surname: Dzoyem fullname: Dzoyem, Jean Paul organization: Department of Biochemistry Faculty of Science University of Dschang, Dschang, Cameroon |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39026629$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2024 Adamu Imam Isa et al. Copyright © 2024 Adamu Imam Isa et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2024 Adamu Imam Isa et al. 2024 |
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| Snippet | is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms underlying this... Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain‐related conditions. However, the anti‐inflammatory mechanisms... Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms... Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain-related conditions. However, the anti-inflammatory mechanisms... |
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| SubjectTerms | Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Cell proliferation Chromatography Cytokines Cytokines - metabolism Dorstenia Enzymes Ficusin - chemistry Ficusin - pharmacology Herbal medicine Infections Inflammation Inflammatory diseases Interleukins Lipopolysaccharides - pharmacology Lipoxygenase Lymphocytes T Macrophages Macrophages - drug effects Macrophages - metabolism Medical research Medicinal plants Mice Natural products Nitric oxide Nitric Oxide - metabolism Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Prostaglandin endoperoxide synthase Psoralen RAW 264.7 Cells Th1 Cells - drug effects Th1 Cells - metabolism Th2 Cells - drug effects Th2 Cells - metabolism Tumor necrosis factor-α Viral infections γ-Interferon |
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| Title | Psoralen Isolated from the Roots of Dorstenia psilurus Welw. Modulate Th1/Th2 Cytokines and Inflammatory Enzymes in LPS-Stimulated RAW 264.7 Macrophages |
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