Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy

• Published in: Gene Vol. 892; p. 147886
• Main Authors: Saleh Faisal, Muhammad, Jamil, Ayesha, Ali, Niaz, Alshahrani, Abdulrahman M., Almarshad, Feras
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 20.01.2024
• Subjects: blood; Carbamazepine; Epilepsy; genes; genetic polymorphism; heterozygosity; homozygosity; males; Pakistan; pharmacokinetics; reversed-phase high performance liquid chromatography; Sanger sequencing; therapeutics; UGT gene polymorphism; Valproic acid; Pakistan; UGT; ILAE; Epilepsy; VPA; IS; Valproic acid; AEDs; Carbamazepine; CDR; SNP; RFTs; GTC; HWE; CBZ; LFTs; Sanger sequencing; TDM; HPLC; UGT gene polymorphism

•Aim of study was to determine UGT gene polymorphism and its impact on VPA and CBZ metabolism.•Homozygous and heterozygous variants of UGT genes were appreciably high in Khyber Pakhtunkhwa population of Pakistan compared to ethnic groups of other countries.•Genetic polymorphisms of UGT1A6 decreased...