Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells

• Published in: Journal of microencapsulation Vol. 38; no. 6; pp. 381 - 393
• Main Authors: Colpan, Reyhan Dilsu, Erdemir, Aysegul
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.08.2021
• Subjects: anti-cancer; caffeic-acid phenethyl ester; colon cancer; Colonic Neoplasms - drug therapy; Esters; Humans; nanoparticle; Nanoparticles; Particle Size; Polyglycolic Acid; Quercetin; Quercetin - pharmacology; nanoparticle; caffeic-acid phenethyl ester; anti-cancer; colon cancer; Quercetin

This study aimed to synthesise quercetin- caffeic-acid phenethyl ester (CAPE)-co-loaded poly(lactic-co-glycolic-acid) (PLGA) nanoparticles (QuCaNP) and investigate their anti-cancer activity on human colorectal carcinoma HT-29 cells. QuCaNPs were synthesised using single-emulsion (o/w) solvent evapo...