Aurora kinase inhibitors: a patent review (2014-2020)

• Published in: Expert opinion on therapeutic patents p. 1
• Main Authors: Jing, Xue-Li, Chen, Shi-Wu
• Format: Journal Article
• Language: English
• Published: England 03.07.2021
• Subjects: aurora kinase; combination therapy; clinical trials; patent; inhibitor; anticancer

: Aurora kinases are a family of serine/threonine kinases, and promote mitotic spindle assembly by regulating centrosome duplication and separation. Aurora kinases are overexpressed in a variety of tumor cell lines, thus, the use of Aurora kinase small-molecule inhibitors has become a potential trea...