Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis

• Published in: Frontiers in immunology Vol. 16; p. 1559966
• Main Authors: Zheng, Ziyi, Lin, Lin, Lin, Huifang, Zhou, Jie, Wang, Zhe, Wang, Yang, Chen, Jianxin, Lai, Caimin, Li, Renfu, Shen, Zhiyong, Zhong, Ming, Xie, Cheng, Chen, Yinjian, Zhang, Xuechao, Guo, Zhongjie, Dong, Rui, He, Shiwei, Chen, Feng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: acetylcholine; Acetylcholine - metabolism; Animals; Disease Models, Animal; Ednrb-/- mice; Enterocolitis - etiology; Enterocolitis - immunology; Enterocolitis - metabolism; Enterocolitis - pathology; Hirschsprung Disease - complications; Hirschsprung Disease - immunology; Hirschsprung Disease - metabolism; Hirschsprung-associated enterocolitis; Hirschsprung’s disease; Humans; Macrophage Activation; macrophages; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Knockout; Tuft Cells; macrophages; tuft cells; Ednrb-/- mice; Hirschsprung-associated enterocolitis; acetylcholine; Ednrb-; Hirschsprung’s disease

Hirschsprung-associated enterocolitis (HAEC) is one of the most severe complications in patients with Hirschsprung's disease (HSCR). Previous research has indicated that acetylcholine (ACH) plays an anti-inflammatory role during inflammation by acting on the α7 nicotinic acetylcholine receptor(...