Elevated plasma levels of D-serine in some patients with amyotrophic lateral sclerosis

• Published in: Amyotrophic lateral sclerosis and frontotemporal degeneration Vol. 22; no. 3-4; pp. 206 - 210
• Main Authors: Lee, Aven, Arachchige, Buddhika Jayakody, Henderson, Robert, Pow, David, Reed, Sarah, Aylward, James, McCombe, Pamela Ann
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2021
• Subjects: Amyotrophic lateral sclerosis; D-serine; mass spectrometry; Amyotrophic lateral sclerosis; mass spectrometry; D-serine

D-serine is an endogenous co-agonist with glutamate for activation of the N-methyl-D-aspartate receptor (NMDAR). D-serine exacerbates neuronal death and is elevated in the spinal cord from patients with sporadic/familial ALS. The present study was undertaken to examine whether plasma levels of D-ser...