Bidirectional relationship between serum creatinine to cystatin C ratio and chronic kidney disease: a mediation analysis of depression in a national aging cohort

• Published in: Frontiers in psychiatry Vol. 16; p. 1554695
• Main Authors: Cai, Qiong, Zhong, Qing, Ali, Sajid, Yang, Wenting, Chen, Yanan, Ao, Bo, Huang, Youliang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: all-cause mortality; chronic kidney disease; depressive symptoms; mediating effect; serum creatinine to cystatin C ratio; chronic kidney disease; mediating effect; depressive symptoms; serum creatinine to cystatin C ratio; all-cause mortality

CCR is an emerging biomarker for renal function, yet its relationship with depression and CKD risk has not been confirmed and is understudied in the population. This study aimed to investigate the association between CCR and CKD, as well as all-cause mortality, among middle-aged and elderly Chinese...