Preparation and evaluation of a chitosan-coated antioxidant liposome containing vitamin C and folic acid

• Published in: Journal of microencapsulation Vol. 35; no. 3; pp. 272 - 280
• Main Authors: Jiao, Zhen, Wang, Xiudong, Yin, Yuting, Xia, Jingxin, Mei, Yanan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2018
• Subjects: antioxidant activity; chitosan; co-loaded antioxidant liposomes; folic acid; Vitamin C; Co-loaded antioxidant liposomes; Chitosan; Antioxidant activity; Folic acid; Vitamin C
• ISSN: 0265-2048; 1464-5246; 1464-5246
• DOI: 10.1080/02652048.2018.1467509

Vitamin C (VC) and folic acid (FA) are the important nutrient and antioxidant in human body. In order to improve their stability, their co-loaded liposomes (VCFA-Lip) and chitosan-coated liposomes (CS-VCFA-Lip) are prepared and characterised. The mean particle size of VCFA-Lip and CS-VCFA-Lip is 138 nm and 249 nm, respectively. The encapsulation efficiencies of both drugs for CS-VCFA-Lip are much higher than those for VCFA-Lip. Furthermore, the experimental results show that the antioxidant activity of CS-VCFA-Lip is higher than that of VCFA-Lip. Moreover, the storage stability study reveals that the chitosan coating can efficiently improve the physical stability of VCFA-Lip. These results indicate that stability of VC and FA can be greatly improved after being wrapped by liposomes. In addition, the performance of CS-VCFA-Lip is better than VCFA-Lip, indicating CS-VCFA-Lip can be applied as a promising delivery system for the antioxidant defence system to the food industry and cosmetic industry.