Growth Hormone and Low Dose Estrogen in Turner Syndrome: Results of a United States Multi-Center Trial to Near-Final Height

• Published in: The journal of clinical endocrinology and metabolism Vol. 87; no. 5; pp. 2033 - 2041
• Main Authors: Quigley, Charmian A., Crowe, Brenda J., Anglin, D. Greg, Chipman, John J.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.05.2002; Endocrine Society
• Subjects: Age; Biological and medical sciences; Body height; Body Height - drug effects; Body weight; Child; Dose-Response Relationship, Drug; Double-Blind Method; Estradiol Congeners - administration & dosage; Estradiol Congeners - adverse effects; Estradiol Congeners - therapeutic use; Estrogens; Ethinyl Estradiol - administration & dosage; Ethinyl Estradiol - adverse effects; Ethinyl Estradiol - therapeutic use; Female; Genetic disorders; Growth hormones; Gynecology. Andrology. Obstetrics; Hormones. Endocrine system; Human Growth Hormone - adverse effects; Human Growth Hormone - therapeutic use; Humans; Longitudinal Studies; Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance; Medical sciences; Pharmacology. Drug treatments; Placebos; Recombinant Proteins - adverse effects; Recombinant Proteins - therapeutic use; Safety; Treatment Outcome; Turner Syndrome - drug therapy; Turner Syndrome - pathology; Turner's syndrome; United States; North America; America; United States > US; Chromosomal aberration; Human; Dysgenesia; Low dose; Estrogen; Somatotropin hormone; Oral administration; Sexual differentiation disorder; Turner syndrome; Long term; Female genital diseases; Randomization; Malformation; Gonad; Bone age; Adult; Female; Failure; Comparative study

A cardinal clinical feature of Turner syndrome (TS) is linear growth failure resulting in extreme short stature: the median adult height of untreated women with TS is 143 cm, 20 cm (8 in.) below that of the general female population. In the largest multicenter, randomized, long-term, dose-response s...