Helicobacter pylori: past, current and future treatment strategies with gastroretentive drug delivery systems

• Published in: Journal of drug targeting Vol. 24; no. 10; pp. 897 - 915
• Main Authors: Verma, Anurag, Dubey, Juhi, Hegde, Rahul Rama, Rastogi, Vaibhav, Pandit, J. K.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 25.11.2016
• Subjects: Adhesive systems; Antacids - administration & dosage; Antacids - pharmacokinetics; Antacids - therapeutic use; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Drug Delivery Systems - methods; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Gastric Mucosa - microbiology; GRDDS; H. pylori; Helicobacter Infections - drug therapy; Helicobacter Infections - microbiology; Helicobacter pylori - drug effects; Humans; in situ gelling systems; polymeric rafts; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - pharmacokinetics; Proton Pump Inhibitors - therapeutic use; H. pylori; polymeric rafts; in situ gelling systems; GRDDS; Adhesive systems

Helicobacter pylori have been subject to intense investigation since its discovery from gastric biopsy in 1982. This gastropathogen has been regarded as serious public health problem due to its association with dyspepsia, gastritis, gastroduodenal ulcers, mucus-associated lymphoid tissue lymphoma an...