Outcomes of cochlear implants in patients with PCDH15 mutations: a clinical study

• Published in: Frontiers in genetics Vol. 16; p. 1541333
• Main Authors: Bi, Qingling, Chen, Zhongyan, Kang, Baoling, Lv, Yong, Yuan, Yongyi, Liu, Yang, Liu, Jianfeng, Li, Yuan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: auditory and speech outcomes; cochlear implantation; genetic mutations; PCDH15 gene; sensorineural hearing loss; usher syndrome; sensorineural hearing loss; PCDH15 gene; genetic mutations; auditory and speech outcomes; cochlear implantation; usher syndrome

To explore molecular diagnoses in cochlear implantation (CI) recipients and evaluate CI outcomes in patients with mutations. Whole-exome sequencing and biomedical informatics were used to identify potential genetic causes in 467 individuals with congenital sensorineural hearing loss. We reviewed six...