Decreased Expression of Glial-Derived Neurotrophic Factor Receptors in Glaucomatous Human Retinas

• Published in: Current eye research Vol. 47; no. 4; pp. 597 - 605
• Main Authors: Akurathi, Abhigna, Boese, Erin A., Kardon, Randy H., Ledolter, Johannes, Kuehn, Markus H., Harper, Matthew M.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2022
• Subjects: Ciliary Neurotrophic Factor - metabolism; Ciliary Neurotrophic Factor Receptor alpha Subunit - metabolism; CNTF; GDNF; glaucoma; Glaucoma - diagnosis; Glaucoma - metabolism; Glial Cell Line-Derived Neurotrophic Factor - metabolism; Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism; Humans; neuroprotection; neurotrophic growth factor; Retina - metabolism; Retinal Ganglion Cells - metabolism; CNTF; GDNF; glaucoma; neuroprotection; neurotrophic growth factor

The purpose of this study was to examine the expression of glial-derived neurotrophic factor (GDNF), the GDNF receptors GFRα1 and GFRα2, ciliary neurotrophic factor (CNTF), and the CNTF receptor CNTFRα in normal and glaucomatous human tissue. Human retinas were collected from 8 donors that had been...