Zinc-based metal-organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study

Development of biomedical systems for controllable drug delivery systems and construction of biosensors is imperative to reduce side effects of common treatment techniques and enhance the therapeutic efficacy. To address this issue, metal-organic frameworks (MOFs) as hybrid porous polymeric structur...

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Published inDrug metabolism reviews Vol. 51; no. 3; pp. 356 - 377
Main Authors Bahrani, Sonia, Hashemi, Seyyed Alireza, Mousavi, Seyyed Mojtaba, Azhdari, Rouhollah
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.07.2019
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Abstract Development of biomedical systems for controllable drug delivery systems and construction of biosensors is imperative to reduce side effects of common treatment techniques and enhance the therapeutic efficacy. To address this issue, metal-organic frameworks (MOFs) as hybrid porous polymeric structures have attracted worldwide attention due to their unprecedented opportunities in vast range of applications in diverse fields including chemistry, biological, and medicinal science as gas storage/separation, sensing, and drug delivery systems. Recently, biomedical application has become an interesting and promising issue for development and usage of multi-functional MOFs. Flexible chemical composition and versatile porous structure of MOFs enable the engineering and enhancement of their medical formulation and functionality as practical carriers for whether therapeutic or imaging agents. One important point in this domain is the efficient delivery of drugs in the body using nontoxic and biodegradable carriers. This review brings together the literatures that addressing the biomedical applications of Zinc-based MOFs (i.e. as drug delivery systems or nontoxic agent in matter of therapeutic applications) to present recent achievements in this interesting field.
AbstractList Development of biomedical systems for controllable drug delivery systems and construction of biosensors is imperative to reduce side effects of common treatment techniques and enhance the therapeutic efficacy. To address this issue, metal-organic frameworks (MOFs) as hybrid porous polymeric structures have attracted worldwide attention due to their unprecedented opportunities in vast range of applications in diverse fields including chemistry, biological, and medicinal science as gas storage/separation, sensing, and drug delivery systems. Recently, biomedical application has become an interesting and promising issue for development and usage of multi-functional MOFs. Flexible chemical composition and versatile porous structure of MOFs enable the engineering and enhancement of their medical formulation and functionality as practical carriers for whether therapeutic or imaging agents. One important point in this domain is the efficient delivery of drugs in the body using nontoxic and biodegradable carriers. This review brings together the literatures that addressing the biomedical applications of Zinc-based MOFs (i.e. as drug delivery systems or nontoxic agent in matter of therapeutic applications) to present recent achievements in this interesting field.
Author Azhdari, Rouhollah
Mousavi, Seyyed Mojtaba
Bahrani, Sonia
Hashemi, Seyyed Alireza
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  email: sa_hashemi@sums.ac.ir
  organization: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences
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  givenname: Seyyed Mojtaba
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  givenname: Rouhollah
  surname: Azhdari
  fullname: Azhdari, Rouhollah
  organization: Faculty of Chemical, Petroleum and Gas, Semnan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31203696$$D View this record in MEDLINE/PubMed
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Zinc-based metal–organic frameworks
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Snippet Development of biomedical systems for controllable drug delivery systems and construction of biosensors is imperative to reduce side effects of common...
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SubjectTerms Animals
Biocompatible Materials - chemistry
Biocompatible Materials - toxicity
Biodegradation, Environmental
biomedical application
Biosensing Techniques - instrumentation
drug delivery systems
Drug Delivery Systems - instrumentation
Humans
imaging agent
Models, Molecular
Organometallic Compounds - chemistry
Organometallic Compounds - toxicity
Zinc - chemistry
Zinc - toxicity
Zinc-based metal-organic frameworks
Title Zinc-based metal-organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study
URI https://www.tandfonline.com/doi/abs/10.1080/03602532.2019.1632887
https://www.ncbi.nlm.nih.gov/pubmed/31203696
https://search.proquest.com/docview/2242159596
Volume 51
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