Zinc-based metal-organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study
Development of biomedical systems for controllable drug delivery systems and construction of biosensors is imperative to reduce side effects of common treatment techniques and enhance the therapeutic efficacy. To address this issue, metal-organic frameworks (MOFs) as hybrid porous polymeric structur...
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Published in | Drug metabolism reviews Vol. 51; no. 3; pp. 356 - 377 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis
03.07.2019
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Abstract | Development of biomedical systems for controllable drug delivery systems and construction of biosensors is imperative to reduce side effects of common treatment techniques and enhance the therapeutic efficacy. To address this issue, metal-organic frameworks (MOFs) as hybrid porous polymeric structures have attracted worldwide attention due to their unprecedented opportunities in vast range of applications in diverse fields including chemistry, biological, and medicinal science as gas storage/separation, sensing, and drug delivery systems. Recently, biomedical application has become an interesting and promising issue for development and usage of multi-functional MOFs. Flexible chemical composition and versatile porous structure of MOFs enable the engineering and enhancement of their medical formulation and functionality as practical carriers for whether therapeutic or imaging agents. One important point in this domain is the efficient delivery of drugs in the body using nontoxic and biodegradable carriers. This review brings together the literatures that addressing the biomedical applications of Zinc-based MOFs (i.e. as drug delivery systems or nontoxic agent in matter of therapeutic applications) to present recent achievements in this interesting field. |
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AbstractList | Development of biomedical systems for controllable drug delivery systems and construction of biosensors is imperative to reduce side effects of common treatment techniques and enhance the therapeutic efficacy. To address this issue, metal-organic frameworks (MOFs) as hybrid porous polymeric structures have attracted worldwide attention due to their unprecedented opportunities in vast range of applications in diverse fields including chemistry, biological, and medicinal science as gas storage/separation, sensing, and drug delivery systems. Recently, biomedical application has become an interesting and promising issue for development and usage of multi-functional MOFs. Flexible chemical composition and versatile porous structure of MOFs enable the engineering and enhancement of their medical formulation and functionality as practical carriers for whether therapeutic or imaging agents. One important point in this domain is the efficient delivery of drugs in the body using nontoxic and biodegradable carriers. This review brings together the literatures that addressing the biomedical applications of Zinc-based MOFs (i.e. as drug delivery systems or nontoxic agent in matter of therapeutic applications) to present recent achievements in this interesting field. |
Author | Azhdari, Rouhollah Mousavi, Seyyed Mojtaba Bahrani, Sonia Hashemi, Seyyed Alireza |
Author_xml | – sequence: 1 givenname: Sonia surname: Bahrani fullname: Bahrani, Sonia organization: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences – sequence: 2 givenname: Seyyed Alireza surname: Hashemi fullname: Hashemi, Seyyed Alireza email: sa_hashemi@sums.ac.ir organization: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences – sequence: 3 givenname: Seyyed Mojtaba surname: Mousavi fullname: Mousavi, Seyyed Mojtaba organization: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences – sequence: 4 givenname: Rouhollah surname: Azhdari fullname: Azhdari, Rouhollah organization: Faculty of Chemical, Petroleum and Gas, Semnan University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31203696$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Animals Biocompatible Materials - chemistry Biocompatible Materials - toxicity Biodegradation, Environmental biomedical application Biosensing Techniques - instrumentation drug delivery systems Drug Delivery Systems - instrumentation Humans imaging agent Models, Molecular Organometallic Compounds - chemistry Organometallic Compounds - toxicity Zinc - chemistry Zinc - toxicity Zinc-based metal-organic frameworks |
Title | Zinc-based metal-organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study |
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