The effect of double (S238F/W159H) mutations on the structure and dynamics of PET degrading enzyme

• Published in: Journal of biomolecular structure & dynamics Vol. 43; no. 3; pp. 1511 - 1521
• Main Authors: Mhashal, Anil Ranu, Kumar T, Neeraj, Kumar, Nitheeshkumar, Singhal, Anshul, Ravandur, Akash, Sokkar, Pandian, Kulkarni, Naveen
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 11.02.2025
• Subjects: Burkholderiales - enzymology; Burkholderiales - genetics; Catalysis; Catalytic Domain; enzyme engineering; Hydrolysis; Molecular Dynamics Simulation; Mutation; PET; PETase; plastic; polyethylene terephthalate; Polyethylene Terephthalates - chemistry; Polyethylene Terephthalates - metabolism; Protein Conformation; enzyme engineering; plastic; PETase; polyethylene terephthalate; molecular dynamics simulation; Catalysis; PET

Polyethylene terephthalate (PET) is one of the highly produced synthetic polymers worldwide and had acquired attention due to its impact resistance, high clarity, and light weight. PET has become the first choice in making disposable bottles, leading to massive scales of production resulting in very...