CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide

• Published in: Advances in experimental medicine and biology Vol. 417; p. 145
• Main Authors: Mahnke, K, Becher, E, Ricciardi-Castagnoli, P, Luger, T A, Schwarz, T, Grabbe, S
• Format: Journal Article
• Language: English
• Published: United States 1997
• Subjects: Animals; Antigen Presentation; Base Sequence; Cell Line; Cell Membrane - immunology; Cytokines - pharmacology; Dendritic Cells - classification; Dendritic Cells - drug effects; Dendritic Cells - immunology; DNA Primers - genetics; Gene Expression - drug effects; Humans; Interleukin-1 - metabolism; Isoantigens; Lipopolysaccharide Receptors - genetics; Lipopolysaccharide Receptors - metabolism; Lipopolysaccharides - pharmacology; Mice; Ovalbumin - immunology; Phenotype; Polymerase Chain Reaction; RNA, Messenger - genetics; Up-Regulation - drug effects

The CD14 surface molecule is predominantly expressed by cells of myeloid origin and regarded as a specific marker for macrophages (M phi). Thus, in human mononuclear cell preparations, CD14 expression is a widely used parameter to distinguish M phi from dendritic cells (DC). Since a murine homologue...