A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin

• Published in: MedChemComm Vol. 15; no. 4; pp. 1189 - 1197
• Main Authors: Klemt, Insa, Reshetnikov, Viktor, Dutta, Subrata, Bila, Galyna, Bilyy, Rostyslav, Cuartero, Itziar Cossío, Hidalgo, Andrés, Wünsche, Adrian, Böhm, Maximilian, Wondrak, Marit, Kunz-Schughart, Leoni A, Tietze, Rainer, Beierlein, Frank, Imhof, Petra, Gensberger-Reigl, Sabrina, Pischetsrieder, Monika, Körber, Marlies, Jost, Tina, Mokhir, Andriy
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 24.04.2024; RSC
• Subjects: Anticancer properties; Antineoplastic drugs; Antitumor activity; Antitumour agents; Biocompatibility; Camptothecin; Cancer; Cations; Chemistry; Drugs; Hydrogen peroxide; Intermediates; Leukocytes (neutrophilic); Lipophilic; Neutropenia; Neutrophils; Oligomerization; Oligomers; Prodrugs; Side effects

Many known chemotherapeutic anticancer agents exhibit neutropenia as a dose-limiting side effect. In this paper we suggest a prodrug concept solving this problem for camptothecin (HO-cpt). The prodrug is programmed according to Boolean "AND" logic. In the absence of H O (trigger T1), in th...