Characterization of Low-Molecular-Weight Heparins by Strong Anion-Exchange Chromatography

• Published in: Journal of AOAC International Vol. 100; no. 6; pp. 1706 - 1714
• Main Authors: Sadowski, Radosław, Gadzała-Kopciuch, Renata, Kowalkowski, Tomasz, Widomski, Paweł, Jujeczka, Ludwik, Buszewski, Bogusław
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2017
• Subjects: Chromatography; Chromatography, High Pressure Liquid - instrumentation; Chromatography, High Pressure Liquid - methods; Chromatography, Ion Exchange - methods; Chromatography, Ion Exchange - statistics & numerical data; Composition; Dalteparin - analysis; Dalteparin - chemistry; Enoxaparin - analysis; Enoxaparin - chemistry; Factor Analysis, Statistical; Heparin; Heparin Lyase - chemistry; Heparin Lyase - metabolism; Heparin, Low-Molecular-Weight - analysis; Heparin, Low-Molecular-Weight - chemistry; Methods; Nadroparin - analysis; Nadroparin - chemistry

Currently, detailed structural characterization of low-molecular-weight heparin (LMWH) products is an analytical subject of great interest. In this work, we carried out a comprehensive structural analysis of LMWHs and applied a modified pharmacopeial method, as well as methods developed by other res...