PDGFR-β/Cav1-induced autophagy via mTOR/FIP200/ATG13 activation in cancer-associated fibroblasts promotes the malignant progression of breast cancer

• Published in: Journal of translational medicine Vol. 23; no. 1; pp. 784 - 17
• Main Authors: Zhang, Lifang, Wang, Keqin, Zhang, Jianbo, Qian, Xianzhe, Zhang, Xiaoan, Wang, Yi, Hu, Quan, Zhan, Ziyi, Hu, Wending, Lin, Hui, Liu, Xiaoming, Xiong, Lixia
• Format: Journal Article
• Language: English
• Published: England BMC 11.07.2025
• Subjects: Animals; Autophagy; Autophagy-Related Proteins - metabolism; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer-associated fibroblasts; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Caveolin 1 - metabolism; Caveolin-1; Cell Line, Tumor; Cell Movement; Disease Progression; Female; Humans; Mice; Neoplasm Invasiveness; PDGFR-β; Receptor, Platelet-Derived Growth Factor beta - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - metabolism; Tumor Microenvironment; Caveolin-1; Cancer-associated fibroblasts; PDGFR-β; Breast cancer; Autophagy

Breast cancer incidence rates have been increasing globally. Cancer-associated fibroblasts (CAFs), key stromal components of the tumor microenvironment (TME), play crucial roles in tumor growth by dynamically interacting with cancer cells. Autophagy has been extensively studied in multiple stages of...