Association of Human forkhead box protein 3 (FOXP3) gene polymorphisms with idiopathic recurrent pregnancy loss among Kazakhstani women

• Published in: Gene Vol. 801; p. 145835
• Main Authors: Abdukassimova, Meruyert, Kanabekova, Perizat, Bauyrzhanova, Zhansaya, Ukybassova, Talshyn, Kaldygulova, Lyazzat, Imankulova, Balkenzhe, Aimagambetova, Gulzhanat, Almawi, Wassim Y.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 30.10.2021
• Subjects: alleles; case-control studies; confidence interval; FOXP3; gene frequency; genotyping; haplotypes; heterozygosity; homozygosity; linkage disequilibrium; pregnancy; Pregnancy losses; quantitative polymerase chain reaction; Recurrent miscarriages; risk; Single-nucleotide polymorphism; transcription factors; Treg; MAF; OR; CI; Tregs; Treg; LD; Single-nucleotide polymorphism; Pregnancy losses; Recurrent miscarriages; FOXP3; RPL

•Lower (rs2294021) and higher (rs2232365) minor allele frequency was seen in RPL cases.•Increased RPL risk was seen in rs2232365 homozygous minor allele carrying genotype.•Reduced RPL risk was seen in rs2294021 heterozygous and homozygous minor allele genotypes.•RPL-susceptible (TACC) and -protectiv...